(O,O)-二烷基-α-苯基-α-(4-取代芳甲酰氨基)-甲基膦酸酯的合成与波谱表征  

Synthesis and spectral characterizations of(O,O)-dialkyl-α-phenyl-α-(4-substituted benzoylamino)methylphosphonate

作　　者：方华[1] 陈伟珠[1] 张怡评[1] 易瑞灶[1] 洪专[1] 

机构地区：[1]国家海洋局第三海洋研究所,福建厦门361005

出　　处：《化学研究》2015年第6期590-596,600,共8页Chemical Research

基　　金：福建省科技计划重点项目(2014Y0068);海洋公益性行业科研专项经费项目(201405017);海洋经济创新发展区域示范专项(GD2012-D01-001)

摘　　要：通过(O,O)-二烷基-α-苯基-α-氨基亚膦酸酯与4-取代芳基甲酸的缩合反应合成了12种目标化合物,产物结构利用元素分析、红外光谱、核磁共振(1 H NMR、13 C NMR和31P NMR)光谱和质谱进行了表征.为了进一步了解此类化合物的结构,利用X射线单晶衍射测定了化合物4f,4g,4i,4j,4k和4l的单晶结构.分析了化合物4a-4f加氢离子的电喷雾多级质谱裂解规律,解释了重排离子r形成的可能机制.A series of（O,O）-dialkyl-α-phenyl-α-（4-substituted benzoylamino）methylphosphonate were synthesized fromα-aminophosphonate and 4-substituted benzoic acid chloride under ice bath.The products were characterized by elemental analysis,IR,NMR（1 H NMR,13 C NMR and 31 P NMR）and mass spectrometry.In order to further confirmed the structure of these compounds,4f,4g,4i,4j,4kand 4lwere determined by X-ray diffractometer.The protonated molecules[M＋H]＋of compounds 4a-4fwere analyzed under electrospray ionization tandem mass spectrometric conditions,at the same time,attempts were made to explain the possible mechanism of the formation of rearrangement ion.

关 键 词：膦酸酯 波谱表征 质谱裂解 晶体结构 

分 类 号：O627.51[理学—有机化学]