过敏性紫癜患儿免疫功能的变化及临床意义  

Changes and clinical significance of immune function in children with henoch-schonlein purpura

作　　者：张晓娟[1] 高劲[1] 徐国成[1] 沈伊娜[1] 

机构地区：[1]皖南医学院第一附属医院弋矶山医院儿科,安徽芜湖241001

出　　处：《皖南医学院学报》2015年第6期551-553,共3页Journal of Wannan Medical College

摘　　要：目的：研究过敏性紫癜患儿体内免疫功能的变化及意义。方法：选取自2014年5月~2015年5月收住于本院的确诊为过敏性紫癜的50例患儿,对照组为同期门诊体检的50例健康儿童,采用散射比浊法检测两组儿童外周血中的免疫球蛋白水平,流式细胞术检测T淋巴细胞亚群的变化。结果：与对照组相比,过敏性紫癜患儿的Ig A、Ig M升高,而Ig G水平降低;CD8＋水平上升,而CD3＋、CD4＋、CD4＋/CD8＋比例下降,差异有统计学意义（P〈0.01）。结论：过敏性紫癜患儿体内存在体液免疫和细胞免疫功能紊乱。Objective： To investigate the changes and clinical significance of the immune function in children with henoch-schonlein purpura（ HSP）.Methods： Fifty cases diagnosed as HSP were included from May 2014 to 2015,and another 50 healthy subjects underwent physical check-ups at the corresponding period were recruited as controls. Scatter turbidimetry was used to detect the levels of immunoglobulin,and Flow cytometry was performed to determine the levels of T lymphocyte subsets in the two groups. Results： By comparison with the control group,children with HSP had higher levels of Ig A and Ig M,elevated CD8＋level,yet down-regulated levels of CD3＋,CD4＋and CD4＋/ CD8＋. The difference was significant（ P〈0. 01）. Conclusion： Humoral immunity and cellular immunity appear to be disturbed in children with HSP.

关 键 词：过敏性紫癜 儿童 体液免疫 细胞免疫 

分 类 号：R725.5[医药卫生—儿科]