不同来源干细胞治疗糖尿病性足病的原理与效果比较  

Theory and efficacy of stem cells from different sources in the treatment of diabetic foot

作　　者：陈高扬[1] 常非[1] 李锐[1] 张汉阳[1] 董全宇[1] 姜振德 刘茂升[1] 

机构地区：[1]吉林大学第二医院,吉林省长春市130000

出　　处：《中国组织工程研究》2015年第41期6718-6724,共7页Chinese Journal of Tissue Engineering Research

摘　　要：背景:干细胞是一种具有自我复制能力的多潜能细胞,在一定条件下,它可以分化成多种细胞,并且干细胞富含多种生长因子,诱导生成血管和神经,改善下肢血运,从而达到治疗和预防下肢缺血。目的:总结近年来国内外应用不同来源干细胞治疗糖尿病的原理及治疗效果比较。方法:文章由第一作者和第二作者于2015年4至6月期间检索Pub Med、Sciencedirect、Medline数据库2000年1月至2015年1月的相关文章。限定文章语言种类为English,检索词为"diabetic foot,pathogenesis,stem cell therapy",初检文章186篇,筛选后对44篇文章进行分类总结。结果与结论:干细胞可成为治疗糖尿病性足病的新选择,接受干细胞治疗后相应症状缓解,包括血管的生成、侧支的重塑,运动神经传导速度、神经反射的改善,皮肤痛温触觉的改善,疼痛的缓解等。异体源性干细胞的安全性尚不明确,而自体源性干细胞,尤其是骨髓间充质干细胞,能够更好修复已损伤的血管神经,恢复微循环的血供。当前,还需要做更多的基础及临床研究来证实干细胞治疗糖尿病足的安全性和有效性,以及糖尿病患者本身干细胞分化及分泌活性较普通人是否存在差异,让干细胞在糖尿病足治疗中充分发挥其作用。BACKGROUND： Stem cell is a kind of pluripotent cells with self-replication ability, which can differentiate into various cells under certain conditions. Furthermore, stem cells are rich in a variety of growth factors, which can induce the generation of vessels and nerves, and improve the blood supply of lower limbs, thereby achieving the treatment and preventions of lower limb ischemia OBJECTIVE： To summarize and compare the recent achievements in the theory and therapeutic efficacy of stem cells from different sources in the treatment of diabetic foot. METHODS： The first and second authors retrieved Pub Med, Sciencedirect and Medline databases for relevant articles published from January 2000 to January 2015. The key words were ＂diabetic foot, pathogenesis, stem cell therapy＂ in English. Initially, 186 articles were retrieved, and finally 44 articles were included in result analysis. RESULTS AND CONCLUSION： Stem cells can be a new choice for the treatment of diabetic foot. After stem cell therapy, corresponding symptoms have been alleviated, including the generation of new blood vessels and thereshaping of the collateral vessels, the improvement of motor nerve conduction velocity and nerve reflex, the improvement of the sense of skin pain and temperature, and pain relief. It is still unclear whether allogeneic stem cells are safe or not, but autologous stem cells, especially bone marrow mesenchymal stem cells, can be better able to repair damaged vessels and nerves and restore the microcirculation of blood supply. Currently, we need to do more basic and clinical researches to solve the following problems： to confirm the effectiveness and safety of stem cell therapy for diabetic foot; to identify whether there is a difference in the differentiation and secretory activity between stem cells in diabetic patients and ordinary people; to give full play to the treatment of diabetic foot.

关 键 词：糖尿病足 细胞因子类 间质干细胞 单核细胞 组织工程 干细胞 移植 糖尿病性足病 间充质干细胞 细胞因子 机制 效果 

分 类 号：R318[医药卫生—生物医学工程]