失下牙槽神经支配与拔牙窝新骨形成及骨量保持  

Denervation of the inferior alveolar nerve is associated with bone formation and bone mass maintenance in extraction sockets

作　　者：王承勇[1,2] 陈伟辉[1,2] 卢萌[1,2] 王锦[1,2] 茅传青 林海 

机构地区：[1]福建医科大学牙颌面畸形防治研究室,福建省福州市350001 [2]福建医科大学附属协和医院口腔颌面外科,福建省福州市350001 [3]厦门市口腔医院种植科,福建省厦门市361000

出　　处：《中国组织工程研究》2015年第42期6740-6745,共6页Chinese Journal of Tissue Engineering Research

基　　金：国家自然科学基金(31070838);福建省自然科学基金杰出青年项目(2012J06017);福建省卫生厅青年基金(2012-1-20)~~

摘　　要：背景:牙齿拔除后拔牙窝内新骨形成及改建与神经支配密切相关。目的:探讨失神经支配对拔牙窝新骨形成和骨量保持的可能调节作用。方法:切除犬一侧下牙槽神经建立失神经支配动物模型,失神经支配侧为实验组,以未切除侧为对照组,组织学染色检测术后2,4,8,12周时间点拔牙窝新骨形成和骨量保持。结果与结论:实验组拔牙窝骨缺损区的新生骨量面积百分比在术后2,4,8周明显低于对照组(P<0.01);术后2,4,8,12周,实验组颊舌侧牙槽嵴高度差明显高于对照组(P<0.05或P<0.01)。说明失神经支配与拔牙窝新骨形成和骨量保持存在密切相关性。BACKGROUND： There is a close relationship between innervations and bone formation and bone mass maintenance in the extraction sockets. OBJECTIVE：To study the possible effect of denervations on the regulation of new bone formation and bone mass maintenance in the extraction sockets. METHODS：The unilateral inferior nerve of dogs was sectioned to establish an animal denervation model. The normal side was used as control. After model establishment, the premolars of denervated side and normal side were extracted. Histological method was used to test new bone formation and bone mass maintenance in the extraction sockets at the 2nd, 4th, 8th and 12th weeks after tooth extraction. RESULTS AND CONCLUSION：The percentage of new bone areas in the extraction sockets was significantly lower in the experiment group than the control group at weeks 2, 4, 8 after tooth extraction （P ＆lt; 0.01）. The height difference between the buccal and lingual alveolar ridge was higher in the experimental group than the control group at weeks 2, 4, 8, 12 after tooth extraction （P ＆lt; 0.05 or P ＆lt; 0.01）. These findings indicate that denervation is closely related with new bone formation and bone mass maintenance in the extraction sockets.

关 键 词：组织构建 骨组织工程 神经支配 失神经支配 拔牙窝 骨愈合 骨量 国家自然科学基金 

分 类 号：R318[医药卫生—生物医学工程]