胰岛素样生长因子在正畸牙牙周组织改建中的作用  

Role of insulin-like growth factor in the orthodontic periodontal tissue remodeling

作　　者：郎遥玲 管晓燕[1,2] 刘建国[1,2] 

机构地区：[1]遵义医学院口腔学院,贵州省遵义市563000 [2]贵州省高等学校口腔疾病研究特色重点实验室,遵义市口腔疾病研究重点实验室,贵州省遵义市563000

出　　处：《中国组织工程研究》2015年第42期6826-6831,共6页Chinese Journal of Tissue Engineering Research

基　　金：贵州省科技创新人才团队建设项目(黔科合人才团队[2013]4026号);贵州省高等学校重点学科建设项目(SZXK-201207-04);贵州省高等学校特色重点实验室建设项目(黔教合KY字[2013]109号);省市科技合作专项资金项目(省市科合[2014]41号)~~

摘　　要：背景:正畸牙牙周组织改建主要是牙槽骨的改建。胰岛素样生长因子是牙周组织改建的重要因子,它在细胞的增殖、分化及个体的生长发育中发挥着重要的促进作用。目的:综述胰岛素样生长因子在牙周组织改建中的作用。方法:运用计算机检索Pub Med,中国知网以及贵州省数字图书馆等数据库,查阅至今有关胰岛素样生长因子在牙周组织改建中作用的中英文文献。关键词"胰岛素样生长因子;牙周组织;改建;insulin-like growth factor;Periodontal tissue;remodeling"。纳入胰岛素样生长因子与牙周组织改建中作用相关的文献进行归纳分析。结果与结论:胰岛素样生长因子属于胰岛素家族的一类多肽,对牙周膜中的成骨细胞、成纤维细胞以及诱导间充质细胞等,有促进其细胞迁移、增殖、分化、胶原和基质合成、增强碱性磷酸酶活性及在损伤修复中发挥着重要作用。在正畸治疗中,使用适宜矫治力的同时可适当运用能促进牙周组织改建的胰岛素样生长因子,加快正畸牙齿的移动,缩短患者的矫治时间。BACKGROUND：Orthodontic treatment is a mechanical force for tooth to cause the remodeling of periodontal tissue, produced by the tooth movement. The main aspect of orthodontic periodontal tissue remodeling is the alveolar bone. Insulin-like growth factor is an important factor in the remodeling of periodontal tissue, which plays an important role in the growth, differentiation and growth of the cels. OBJECTIVE：To review the role of insulin-like growth factors in periodontal tissue remodeling.＆amp;nbsp;METHODS： A computer-based retrieval of PubMed, CNKI and Guizhou Province Digital Library Database was performed to search articles related to the role of insulin-like growth factors in periodontal tissue remodeling. The keywords were “insulin-like growth factor; periodontal tissue; remodeling” in English and Chinese, respectively. RESULTS AND CONCLUSION： Insulin like growth factor belongs to the insulin family, a kind of peptides, which can promote the migration, proliferation, differentiation, colagen and matrix synthesis and alkaline phosphatase activity of osteoblasts, fibroblasts and mesenchymal cels in the periodontal ligament. It also plays an important role in the repair of injury. During orthodontic treatment, the use of suitable orthodontic force combined with insulin-like growth factor can promote periodontal tissue remodeling, accelerate the orthodontic tooth movement and shorten the treatment time for patients.

关 键 词：组织构建 组织工程 胰岛素样生长因子 牙周组织 改建 牙周膜成纤维细胞 成骨细胞 破骨细胞 碱性磷酸酶 

分 类 号：R318[医药卫生—生物医学工程]