结构特征对磷酸钙陶瓷骨诱导活性的影响  

Structural properties influence the osteoinduction of calcium phosphate ceramics

作　　者：孟磊[1,2] 甄平[2] 梁晓燕[2] 曹雪飞[2] 

机构地区：[1]甘肃中医药大学,甘肃省兰州市730000 [2]解放军兰州军区兰州总医院全军骨科中心,甘肃省兰州市730050

出　　处：《中国组织工程研究》2015年第43期7010-7016,共7页Chinese Journal of Tissue Engineering Research

基　　金：国家自然科学基金面上项目(81371983):多孔β-TCP负载PLGA抗结核药物缓释微球的构建及其抗结核成骨作用研究~~

摘　　要：背景:目前关于磷酸钙陶瓷诱导成骨的机制尚不完全清楚,许多学者试图从材料的结构特征方面去阐明磷酸钙陶瓷诱导成骨的机制。目的:综述结构特征如何影响磷酸钙陶瓷的骨诱导活性。方法:使用计算机检索Pub Med和谷歌学术数据库中1997年1月至2015年3月关于磷酸钙骨组织工程的文献,排除观点陈旧和重复的文章,最后对60篇文章进行归纳总结。结果与结论:磷酸钙陶瓷的结构可分宏观结构和微观结构,宏观结构包括宏孔、孔洞或管道及颗粒间的间隙等;微观结构包括微孔、颗粒大小、表面粗糙度、比表面积等。结构特征的中各个参数都以一定的方式影响磷酸钙陶瓷的生物活性,使其诱导成骨能力发生着从无到有、从弱到强的变化。但是骨诱导活性的优化并非仅仅依靠结构设计就能达到目的,因为磷酸钙陶瓷的物理化学性质同样也会影响其在体内的生物活性。因此,磷酸钙陶瓷结构设计需要"因地制宜"地与其自身的物理化学性质"完美契合",以获得最佳的骨诱导活性。BACKGROUND： Currently,the mechanism by which calcium phosphate ceramics induces osteogenesis is not fully understood,and many scholars have tried to expound the mechanism from the perspective of the structural properties. OBJECTIVE： To review how the structural properties of calcium phosphate ceramics affect their osteoinductive activity.METHODS： The Pub Med database and Google academic database（1997-01/2015-03） were searched to retrieve the related articles about the structural properties of calcium phosphate ceramics affecting their osteoinductive activity. After the articles with outdated reviews or repetitive contents were ruled out,60 articles were suitable for further analysis and review. RESULTS AND CONCLUSION： The structural properties of calcium phosphate ceramics are displayed by macrostructure,such as macropores,holes,pipes and space between particles,and microstructure,such as micropore,particle size,surface roughness,specific surface area. Each parameter of the structural properties affects the bioactivities of calcium phosphate ceramics in some way,which renders their abilities of inducing osteogenesis to arise from nothing or change from weakly to strongly. Apart from structure design,physical andchemical properties of calcium phosphate ceramics will also affect its biological activity in vivo. Therefore,the physicochemical properties of calcium phosphate ceramics should be considered in the structure design in order to achieve an optimal osteoinductive activity.

关 键 词：磷酸钙类 陶瓷制品 组织工程 生物材料 骨生物材料 磷酸钙陶瓷 骨诱导活性 宏孔 孔隙率 贯通性 表面粗糙 国家自然科学基金 组织构建 

分 类 号：R318[医药卫生—生物医学工程]