磷酸钙材料在骨软骨缺损修复支架中的应用  

Calcium phosphate as a scaffold for repair of osteochondral defects

作　　者：蔡筑韵[1] 彭帆[1] 訾云鹏 吴海山[1] 钱齐荣[1] 

机构地区：[1]解放军第二军医大学附属长征医院骨科,上海市200003

出　　处：《中国组织工程研究》2015年第43期7017-7022,共6页Chinese Journal of Tissue Engineering Research

基　　金：上海市自然科学基金项目(09ZR1410100);国家自然科学基金面上项目(81171727)~~

摘　　要：背景:磷酸钙材料与天然骨矿物质相似,具有良好的生物活性、骨传导性和可降解性,在金属植入物涂层及骨缺损修复材料中已有大量研究与应用。目的:综述不同物相磷酸钙材料的特点及在骨软骨支架中的应用。方法:应用计算机检索Pub Med数据库、中国学术期刊网络出版总库、维普数据库2000年1月至2015年2月的有关文章,中文检索词为"骨软骨,磷酸钙(包括羟基磷灰石、磷酸三钙、聚磷酸钙等),组织工程",英文检索词为"osteochondral;calcium phosphate;tissue engineering"。结果与结论:由于磷酸钙具有多种物相和晶型,通过不同工艺方法调控磷酸钙的结构尺寸可以得到丰富的材料体系,如羟基磷灰石、磷酸三钙、聚磷酸钙、无定形磷酸钙等,其生物学性能和力学性能均有所差异,其中以羟基磷灰石的应用最为广泛。将磷酸钙与其他材料复合制备多层的复合支架是骨软骨组织工程研究的一个趋势。BACKGROUND： Calcium phosphate has the similar mineral component of natural bones with good bioactivity,osteoconductivity and degradability. It has been widely used in bone defect repair and coatings of implants. OBJECTIVE： To review the major properties of different-phase calcium phosphate and to summarize the application of calcium phosphate in scaffolds for osteochondral tissue engineering. METHODS： A computer-based search of Pub Med,CNKI and VIP database was performed for relevant articles published from January 2000 to February 2015 with the key words of ＂osteochondral; calcium phosphate（including hydroxyapatite,tricalcium phosphate,calcium polyphosphate）; tissue engineering＂ in Chinese and English,respectively. RESULTS AND CONCLUSION： Since the calcium phosphate has a variety of phases and crystalline types,a variety of materials with different structure and size can be obtained using different techniques,such as hydroxyapatite,tricalcium phosphate,calcium polyphosphate,amorphous calcium phosphate. These materials have some differences in their biological and mechanical properties,and hydroxyapatite is the most widely used Biocomposite scaffolds with calcium phosphates appeared to have promising potential in osteochondral tissue engineering.

关 键 词：磷酸钙类 组织工程 综述 生物材料 骨生物材料 磷酸钙 骨软骨损伤 关节损伤 无机材料 修复 组织构建 国家自然科学基金 

分 类 号：R318[医药卫生—生物医学工程]