细菌纤维素与纳米银复合制备创伤敷料  

A wound dressing made of nanosilver and bacterial cellulose

作　　者：南方[1] 赖琛[2] 奚廷斐[1,2] 

机构地区：[1]温州医科大学检验医学院生命科学学院,浙江省温州市325035 [2]北京大学深圳研究院人体组织再生与修复深圳重点实验室,广东省深圳市518057

出　　处：《中国组织工程研究》2015年第43期7023-7028,共6页Chinese Journal of Tissue Engineering Research

基　　金：深圳市基础研究项目(JCYJ20130402164725011)~~

摘　　要：背景:近年来,采用纳米复合技术改良细菌纤维素赋予其新性能的研究越来越多。目的:综述细菌纤维素与纳米银复合制备创伤敷料的方法。方法:应用计算机检索2013年1月至2015年4月Pub Med数据库及2007年1月至2015年4月CNKI数据库有关细菌纤维素、纳米银及其复合方式与应用的文献,检索词为"Bacterial Cellulose、Nano-silver,细菌纤维素、纳米银。"结果与结论:制备细菌纤维素纳米银复合物的方式主要有溶液浸渍、原位复合及生物复合3种。溶液浸渍法可降低纤维矩阵中纳米银的离子浓度,使银离子释放高度可控,但遗传毒性及生物相容性有待测试。原位复合法减少了对纤维素网状结构的破坏,使银离子牢固地结合在其表面,减少对细胞的毒害作用,但使用的还原剂毒性较高,还原剂在纤维素内的残留问题不易解决。生物复合工艺中无有毒物质生成,对环境友好,合成的生物材料对人体产生的危害少且反应高度可控。BACKGROUND： In recent years,bacterial cellulose modified by nano-composite technology has been endowed with new properties. OBJECTIVE： To review the combination of bacterial cellulose and nanosilver to prepare wound dressing. METHODS： A computer-online search was performed in Pub Med（2013-01/2015-04） and CNKI（2007-01/2015-04） databases to retrieve studies on bacterial cellulose,nanosilver and their compound method and application using the key words of ＂bacterial cellulose,nano-silver＂ in English and Chinese,respectively. RESULTS AND CONCLUSION： Bacterial cellulose/nano-silver compound can be prepared by three methods： solution impregnation,in situ composite and biocomposite. Solution impregnation method can lower the concentration of nanosilver ions in the fiber matrix to highly control the release of silver ions,but the genetic toxicity and biocompatibility are unclear. In situ composite method can reduce the damage to the mesh structure of cellulose on which silver ions can be bonded firmly to reduce the toxic damage to cells,but the reducing agent used has a higher toxicity,which is difficult to remove. Biocomposite method cannot produce toxic substance,which is friendly to the environment,and the synthetic biomaterials have less harm to the human body and can be controlled highly.

关 键 词：纳米结构 纤维素 生物敷料 组织工程 生物材料 纳米材料 纳米银 细菌纤维素 创伤敷料 纳米复合技术 

分 类 号：R318[医药卫生—生物医学工程]