液中干燥法制备龙胆总苷掩味微囊研究  

Research of Total glycosides of Radix Gentianae Bitter masked microcapsules by drying method in liquid

作　　者：向志芸 李小芳[1] 李培培[1] 周维[1] 李平[1] 罗开沛 

机构地区：[1]成都中医药大学药学院,四川成都611137

出　　处：《亚太传统医药》2015年第23期18-20,共3页Asia-Pacific Traditional Medicine

基　　金：四川省教育厅重点项目(15ZA0094)

摘　　要：目的:运用液中干燥法制备龙胆总苷掩味微囊,星点设计-效应面法优选最优微囊成型工艺。方法:根据预实验和单因素试验结果和星点设计-效应面法设计原理,采用四因素五水平响应面分析方法,以龙胆苦苷的载药量和包封率为考察指标,对乙基纤维素与药物的比例、油水相比例、表面活性剂的用量、乙基纤维素溶液的浓度进行优化,最终确定龙胆总苷掩味微囊的成型工艺。结果:优选的最佳成型工艺为:药物与乙基纤维素的比例为0.6∶1,油水相比例为3∶1,表面活性剂的用量为1.5%,乙基纤维素溶液的浓度为2%,滑石粉与药物的比例为1∶1。结论:星点设计-效应面法优化龙胆总苷掩味微囊的成型工艺效率高,方法简便,预测性好,可用于实验室小量制备,为扩大再生产提供参考依据。Objective：OBJECTIVE Gentian which was prepared by liquid in dry smell millirod covering for total glycosides,star design-response surface method to select the optimal millirod molding process.Methods：According to the results of preliminary experiments and single factor experiment design principle and star design-response surface method,the four factors,five levels of response surface analysis method,with gentian bitter glycosides drug-polymer interactions and envelopment rate as examining index,of ethyl cellulose with medicines,oil-water phase proportion,the proportion of the amount of surfactant,concentration of ethyl cellulose solution is optimized,finally determine the gentian total glycosides mask forming technique of the microcapsule.Results：Select the best molding process is：the drugs and the ratio of ethyl cellulose 0.6,3∶1in oil and water phase,the amount of surfactant was 1.5%,the concentration of a solution of ethyl cellulose was 2%,talcum powder and drug proportion of 1∶1.Conclusion：The composite design-response surface methodology optimization of flavour millirod gentian total glycosides mask molding process of high efficiency,the method is simple,predictability is good,can be used in the laboratory small preparation and provide a reference for expanded reproduction.

关 键 词：龙胆总苷 星点设计-效应面法 掩味微囊 液中干燥法 

分 类 号：R284.1[医药卫生—中药学]