反射式共聚焦激光扫描显微镜在刮痧治疗黄褐斑中的疗效评估价值  

The Application of Reflectance Confocal Microscopy in the Therapeutic Effect Evaluation of Scrapping Treatment for Melasma

作　　者：刘靖华[1] 王红梅[2] 顾安康[2] 李虹[2] 李正风[3] 王慧[3] 房慧媚 赵爽[3] 

机构地区：[1]大连市皮肤病医院皮肤科,辽宁大连116032 [2]天津市中医药研究院附属医院皮肤科,天津300120 [3]天津中医药大学研究生院,天津300193

出　　处：《中国皮肤性病学杂志》2015年第12期1288-1291,共4页The Chinese Journal of Dermatovenereology

摘　　要：目的探讨反射式共聚焦激光扫描显微镜(RCM)在黄褐斑诊断和监测治疗效果中的价值。方法选择2013年4月-2014年6月在天津市中医药研究院附属医院皮肤科门诊就诊的黄褐斑患者24例,均予面部刮痧治疗,1次/周,分别于治疗前和治疗2次、5次和10次时拍摄临床照片和进行RCM检查,并取其中1例典型皮损者进行组织病理学检查。结果黄褐斑患者RCM镜下所见与皮损组织病理检查结果相一致。面部刮痧治疗有效率为66.67%,均未见不良反应。RCM各项指标评分和MASI评分均显著下降(P<0.05)。结论面部刮痧治疗黄褐斑安全有效,RCM可以为黄褐斑诊断和疗效评价提供有力的参考依据。Objective To investigate the clinical significance of reflectance confocal microscopy（RCM） in diagnosis and therapeutic efficacy evaluation of melasma. Methods This study included 24 patients with melasma in our out- patient clinic from April 2013 to June 2014. The patients were given facial scrapping once weekly. In addition to taking photographs,lesions were also examined with RCM before and after 2,5,10 treatments. Skin biopsy was taken from a representative patient for histopathological examination. Results The findings in lesions with RCM were consistent with histopathological examination. The effective rate of facial scrapping was 66. 67% , with no side effect. Following facial scrapping, MASI and RCM scores declined significantly. Conclusion The facial scrapping therapy is effective and safety for melasma. In vivo RCM could be noninvasive method for diag- nosis and evaluation of therapeutic efficacy for melasma.

关 键 词：黄褐斑 反射式共聚焦显微镜 刮痧 

分 类 号：R758.42[医药卫生—皮肤病学与性病学]