CD4^+CD25^+Treg细胞与HBV/HIV感染  

CD4^+CD25^+Treg cells and HBV/HIV infection

作　　者：罗昊翔[1] 顾隆[1] 

机构地区：[1]黔西南民族职业技术学院医药系,贵州兴义562400

出　　处：《现代预防医学》2015年第23期4365-4367,4383,共4页Modern Preventive Medicine

基　　金：贵州省科技厅科学技术基金项目(黔科合J字[2013]2268号)

摘　　要：CD4^+CD25^+Treg细胞是体内重要的免疫调节细胞,可抑制HBV感染导致的免疫病理损伤,在乙肝病人的病情发展中起重要作用。HIV主要感染并破坏CD4^+T细胞,从而导致病人免疫抑制。由于CD4^+CD25^+Treg细胞表面存在CD4分子,HIV也可感染并破坏CD4^+CD25^+Treg细胞,导致体内Treg细胞数量减少,免疫调节功能下降。若HBV/HIV混合感染,CD4^+CD25^+Treg细胞计数有可能作为病人免疫功能状态和病情进展与否的指标,CD4^+CD25^+Treg细胞的数量和功能状态在HIV/HBV混合感染患者的免疫治疗过程中是应该考虑的一个因素。CD4＋CD25＋Treg cells are important immune regulation ceils in vivo, and can inhibit the immunopathogenesis injury caused by HBV infection. So the ceils play an important role in the progression of hepatitis B patients. The CD4＋T cells are the main cells infected and ruined by HIV, then the immune function of the patients will be reduced. Because of the cell marker CD4 molecule in the surface of CD4＋CD25＋Treg cells, HIV can infect and ruin the CD4＋CD25＋Treg cells. The quantity of Treg cells will be reduced and the immunoregulation function will be reduced in vivo. If the patients coinfected with HBV/HIV, the quantity of CD4＋CD25＋Treg cells may be served as an index for judging the statement of immune function of patients and the statement of the illness progressing. The quantity and the statement of CD4＋CD25＋Treg cells function are valuable factors in the processing of immune treatment to HBV/HIV coinfection patients.

关 键 词：TREG细胞 免疫调节 艾滋病 慢性乙型肝炎 混合感染 

分 类 号：R113[医药卫生—公共卫生与预防医学]