临床嗜水气单胞菌感染的特征及药敏分析  

Analysis of Clinical Characteristics and Drug Sensitivity of Aeromonas Hydrophilia Infection

作　　者：任小英[1] 陈海明[1] 赵元勋[1] 郑燕青[1] 马晓波[1] 

机构地区：[1]厦门大学附属第一医院,福建厦门361003

出　　处：《山西职工医学院学报》2015年第5期8-11,共4页Journal of Shanxi Medical College for Continuing Education

摘　　要：目的：分析嗜水气单胞菌的临床特征及药敏特征，为临床诊疗提供依据。方法：纳入2009-2014年厦门某三甲医院临床分离的130例嗜水气单胞菌。细菌的鉴定和药敏采用法国生物梅里埃的 Vitek-2 Compact 全自动微生物分析系统。药敏结果统计采用 WHONET 5．6软件。结果：临床嗜水气单胞菌主要分离自痰标本（25，19．2%）、粪便（23，17．8%）、胆汁（19，14．6%）、伤口分泌物（18，13．8%）和全血（13，10．0%）。嗜水气单胞菌主要分离自住院患者（120例，92．3%）尤其是重症医学科、肝胆外科、消化内科。嗜水气单胞菌对氨苄西林、氨苄西林／舒巴坦、头孢唑林的耐药率最高，均超过90%。未检出替加环素、亚胺培南、美洛培南耐药菌株。阿米卡星、呋喃妥因、哌拉西林／他唑巴坦、庆大霉素、氨曲南、头孢吡肟和左氧氟沙星的体外敏感性大于80%。结论：嗜水气单胞菌感染具有多样性特点，在临床诊治中有待关注。抗菌治疗首选哌拉西林／他唑巴坦和左氧氟沙星。Objective：To analysize clinical characteristics and drug sensitivity of aeromonas hydrophilia infection to provide the basis for clinical diagnosis and antimicrobial therapy. Method：The data from 130 cases of of aeromonashydrophilia clinical isolates were collected from a tertiary hospital in Xiamen from January 2009 to December 2014 . I-dentification and antimicrobial susceptability tests of bacteria were performed by Vitek-2 Compact automatic analysis sys-tem from the French BioM rieux company. Antimicrobial surveillance was carried out with WHONET 5. 6 software. Results：The clinical strains of Aeromonas hydrophilia were mainly isolated from sputum（25,19. 2% ）,feces（23, 17. 8% ）,bile（19,14. 6% ）,wound（18,13. 8% ）,and blood（10% ,13）. Most of bacteria were from hospitalized pa-tients（120 cases,92. 3% ）,especially in Intensive Care Unit（ICU）,department of hepatobiliary surgery,department of internal medicine. The presense of Aeromonas hydrophila resistant to ampicillin,cefazolin,ampicillin / sulbactam was higher than 90% . All aeromonas hydrophilia were sensitive to imipenem,meropenem and tigecycline,and greater than 80% of stains were sensitive to amikacin,nitrofurantoin,piperacillin / tazobactam,gentamicin,aztreonam,cefepime and levofloxacin. Conclusion：Infection caused by Aeromonas hydrophilia has characteristics of diversity. The preferred choice of antimicrobial treatment could be piperacillin / tazobactam and levofloxacin.

关 键 词：嗜水气单胞菌 感染 抗生素 耐药 

分 类 号：R446.6[医药卫生—诊断学]