鲑鱼降钙素联合唑来膦酸治疗老年男性骨质疏松症的效果分析  

Analysis the effect of salmon calcitonin combined with azole phosphonic acid in the treatment of osteoporosis in elderly men

作　　者：冯缨缨[1] 钟远[1] 金俊[1] 

机构地区：[1]上海交通大学附属第六人民医院老年科,上海200233

出　　处：《中国医学前沿杂志（电子版）》2015年第10期98-101,共4页Chinese Journal of the Frontiers of Medical Science(Electronic Version)

摘　　要：目的探究鲑鱼降钙素联合唑来膦酸治疗老年男性骨质疏松症的临床效果。方法将本院收治的173例老年男性骨质疏松症患者随机分为对照组及试验组,两组患者均给予口服钙补充剂,在此基础上对照组患者予以鲑鱼降钙素鼻喷剂,试验组患者予以唑来膦酸注射液,疗程均为1年。比较两组患者临床疗效,治疗前后骨密度（BMD）,血清骨碱性磷酸酶（BAP）、血清I型胶原C端肽（CTX）水平及不良反应发生情况。结果两组患者治疗前BMD比较差异无显著性（P〉0.05）;治疗后两组患者BMD均高于治疗前（P〈0.05）,试验组明显高于对照组（P〈0.05）。试验组患者治疗总有效率明显高于对照组（P〈0.05）。两组患者治疗后BAP水平均较治疗前升高,CTX水平均较治疗前降低（P〈0.05）,治疗后试验组患者BAP水平明显高于对照组（P〈0.05）。两组患者不良反应发生情况比较差异无显著性（χ^2=1.027,P〉0.05）。结论鲑鱼降钙素联合唑来膦酸能够有效增加老年男性骨质疏松症患者BMD,疗效显著,值得临床推广应用。Objective To explore the effect of salmon calcitonin combined with azole phosphonic acid in the treatment of osteoporosis in elderly men.Method 173 cases of elderly male patients with osteoporosis were randomly divided into control group and experimental group,the two groups of patients were given oral calcium supplements,on the basis of the control group patients were given salmon calcitonin nasal spray,experimental group patients were given azole phosphonic acid injection,a course of 1 year.Compared the two groups of patients with clinical efficacy,bone mineral density（BMD） before and after treatment,serum bone alkaline phosphatase（BAP）,serum the C-terminal peptide（CTX） type I collagen levels and adverse reactions.Result There was no significant difference of BMD between the two groups before treatment（P〈0.05）;BMD in both groups after treatment were higher than before treatment（P〈0.05）,experimental group was higher than control group（P〈0.05）.The total effective rate of experimental group patients was higher than control group（P〈0.05）.The level of BAP in the two groups after treatment were higher than before treatment,the CTX levels were lower than before treatment（P〈0.05）,the level of BAP in experimental group was significantly higher than control group（P〈0.05）.There were no significant differences in adverse reactions between the two groups（χ^2= 1.027,P〉0.05）.Conclusion Salmon calcitonin combined with azole phosphonic acid can effectively improve the elderly male patients with osteoporosis bone mineral density,curative effect is distinct,worth of clinical promotion.

关 键 词：鲑鱼降钙素 唑来膦酸 骨质疏松症 

分 类 号：R580[医药卫生—内分泌]