重症药疹预后影响因素及临床特征分析  

Prognosis influence factors and clinical features of severe drug rash

作　　者：畅晓元[1] 宋丹阳[1] 刘岩[1] 

机构地区：[1]沈阳市第七人民医院皮肤一科,沈阳110000

出　　处：《中国当代医药》2015年第33期60-62,共3页China Modern Medicine

摘　　要：目的分析重症药疹的临床特征及致敏药物特点,探讨影响重症药疹临床治疗效果的危险因素。方法对2013年1月-2014年12月就诊于沈阳市第七人民医院的66例因重症药疹入院治疗患者的临床资料进行回顾性分析,根据治疗1周时的治疗效果,将患者分为治疗有效组（43例）及治疗无效组（23例）,分析影响患者治疗效果的危险因素。统计所有患者的发病类型及致敏药物分布特点。结果经单因素及多因素分析显示,患者年龄〉50岁、内脏受累及白蛋白〈30 g/L均为影响患者治疗效果的主要因素（P〈0.05）。在所观察患者的发病类型中以重症多形红斑型发生率最高;致敏药物中以青霉素及头孢菌素类发生率最高。结论重症药疹发病过程中有显著的临床特点及致敏药物特点,且其治疗效果可受多种因素影响。Objective To analyze the clinical features and sensitizing drug features of severe drug rash and explore the risk factors influencing the clinical treatment effects on severe drug rash. Methods Clinical data of 66 patients treated in Shenyang Seventh People′ s Hospital due to severe drug rash from January 2013 to December 2014 were analyzed retrospectively,and the patients were divided into the effective treatment group（43 patients） and the ineffective treatment group（23 patients） according to the 1-week treatment effects.The risk factors influencing the patients′ treatment effects were explored.All the patients′ attack types and distribution features of sensitizing drugs were analyzed. Results Univariate and multivariate analysis showed that patients′ age 50 years,internal organ involvement and albumin 30 g/L were the main factors influencing the patients′ treatment effects（P〈0.05）.Among the attack types of the observed patients,the incidence of severe erythema multiforme was the highest,and among the sensitizing drugs,the incidences of penicillin and cephalosporin were the highest. Conclusion Severe drug rash has remarkable clinical features and sensitizing drug features in the attack process,and its treatment effects may be affected by multiple factors.

关 键 词：重症药疹 回顾性分析 临床特点 致敏药物 

分 类 号：R969.3[医药卫生—药理学]