血清NSE及S-100B检测在手-足-口病严重程度评估中的应用价值  

Application value of detecting NSE and S-100B in serum on the severity of hand-foot-mouth disease

作　　者：江雄 冯战桂 黄中成 

机构地区：[1]深圳市坪山新区妇幼保健院,深圳518122 [2]深圳市坪山新区人民医院,518118

出　　处：《中国当代医药》2015年第33期134-136,共3页China Modern Medicine

摘　　要：目的研究血清神经元特异性烯醇化酶（NSE）及S-100B检测在手-足-口病严重程度评估中的应用价值,为临床诊断和治疗提供理论指导。方法选择2011年3月-2013年7月于我院就诊的40例手-足-口病合并毒性脑炎患儿,31例单纯性手-足-口病患儿及于我院体检的30例健康儿童为研究对象,分别记为重症组、轻度组和对照组。采用酶联免疫吸附试验双抗体夹心法分别检测3组儿童血清中NSE和S-100B的水平,并进行比较。结果重症组和轻度组儿童血清中的NSE及S-100B水平均显著高于对照组,差异有统计学意义（P〈0.05）。重症组患儿血清中的NSE和S-100B水平明显高于轻度组,两组比较差异有统计学意义（P〈0.05）。结论手-足-口病患儿的病情越严重,其血清NSE及S-100B的水平越高,对其检测在手-足-口病严重程度的评估中具有较高的临床参考价值,值得广泛推广和应用。Objective To study the application value of serum NSE and S-100 B detection in the severity evaluation of hand-foot-mouth disease and provide theoretical guidance for clinical diagnosis and treatment. Methods Forty children with hand-foot-mouth disease combined with viral encephalitis treated in our hospital from March 2011 to July2013,31 patients with single hand-foot-mouth disease and 30 healthy children receiving physical examination in our hospital were selected as the study subjects and divided into the severe group,the mild group and the control group.The enzyme linked immunosorbent assay double antibody sandwich method was used to detect and compare the serum NSE and S-100 B levels among three groups of children. Results The severe group and the mild group were significantly higher than the control group in the serum NSE and S-100 B levels,with statistically significant differences（P〈0.05）.The severe group was significantly higher than the mild group in the serum NSE and S-100 B levels,with statistically significant differences（P〈0.05）. Conclusion Children with more severe hand-foot-mouth disease have higher serum NSE and S-100 B levels.Detection of the two indicators has high clinical reference value in the severity evaluation of hand-footmouth disease and thus is worthy of wide promotion and application.

关 键 词：手-足-口病 毒性脑炎 儿童 神经元特异性烯醇化酶 S-100B 

分 类 号：R446.11[医药卫生—诊断学]