埃洛石基阿司匹林表面印迹分离介质的可控制备及表征  

Controlled Preparation and Characterization of Aspirin Surface Molecularly Imprinted Separating Medium Based on Halloysite Nanotubes

作　　者：苏立强[1] 周磊[1] 韩爽[1] 张维冰[1,2] 

机构地区：[1]齐齐哈尔大学化学与化学工程学院,齐齐哈尔161006 [2]华东理工大学上海市功能性材料化学重点实验室,上海200237

出　　处：《分析化学》2015年第11期1772-1776,共5页Chinese Journal of Analytical Chemistry

基　　金：国家自然科学基金(No.121475044);环境保护部项目(No.201209048);黑龙江省教育厅项目(No.12531757)资助~~

摘　　要：以环境友好的天然硅基纳米材料埃洛石为基质,阿司匹林为模板分子,丙烯酰胺为功能单体,采用可逆加成断裂链转移法(RAFT)制备阿司匹林表面印迹分离介质。紫外光谱结合Lamber-Beer理论模型从分子水平上证实印迹体系中模板分子与单体主要以1∶2形式结合成稳定复合物。通过红外光谱、透射电镜及静态吸附、选择性吸附对该印迹材料结构和吸附行为加以研究,结果表明:在埃洛石表面引入了一层厚度约为38 nm、均匀性良好的印迹层。与常规表面印迹及以硅胶为载体的印迹物相比,此印迹材料具有吸附容量高、印迹效果好的特点,印迹因子达到3.5。将印迹材料进一步用于模拟人体肠液扩散实验,印迹材料释药时间(12 h)是非印迹材料释药时间(6 h)的2倍,说明其具有较好释药效果,为可能的载药应用提供了基础数据。The molecularly imprinted separating medium with halloysite nanotubes as carrier,which were environmentally friendly natural silica substrate nano-materials,aspirin as template molecule and acrylamide as functional monomer was synthesized using reversible addition fragmentation chain transfer polymerization. The template molecule and monomer were bound to stable composite at 1 ∶ 2 using the method of ultraviolet spectroscopy combined with Lamber-Beer theory at molecular level. The morphology and adsorption capacity of imprinted material was studied with Fourier transform infrared spectrometer（ FT-IR）,transmission electron microscope（ TEM）,static adsorption and selective adsorption. The experimental results showed that a good uniformity of imprinted layer with the thickness of 38 nm was coated steadily on the halloysite nanotubes surface. Compared with the conventional surface imprinted material and the material with silica gel as carrier,our molecularly imprinted material had the characteristics of high adsorption capacity and favorable imprinted effect. Its imprinted factor achieved to 3. 5. The molecularly imprinted material was applied for mimetic intestinal juice diffusion experiment. The experimental results indicated that the imprinted material release the aspirin for 12 h,which was 2 times for non imprinted material for only 6 h,demonstrating excellent drug release result,which provided basic data for potential applications of drug carrier.

关 键 词：分子印迹聚合物 可逆加成断裂链转移 埃洛石纳米管 吸附特性 

分 类 号：O631.3[理学—高分子化学] TQ460.1[理学—化学]