中国40岁以上人群原发性骨关节炎患病状况调查  

The survey of the prevalence of primary osteoarthritis in the population aged 40 years and over in China

作　　者：薛庆云[1] 王坤正[2] 裴福兴[3] 朱汉民 金大地[5] 陶天遵[6] 李恩[7] 李宁华[8] 张耀南[1] 王晓滨[1] 纪泉[1] 

机构地区：[1]北京医院骨科,100730 [2]西安交通大学医学院第二附属医院骨科 [3]四川大学华西医院骨科,成都 [4]上海华东医院骨质疏松防治研究中心 [5]南方医科大学第三附属医院骨科,广州 [6]哈尔滨医科大学第二附属医院骨科 [7]河北医科大学生物化学教研室,石家庄 [8]卫生部北京老年医学研究所

出　　处：《中华骨科杂志》2015年第12期1206-1212,共7页Chinese Journal of Orthopaedics

基　　金：“十五”国家科技攻关计划课题（2004BA702806）

摘　　要：目的分析中国40岁以上人群原发性骨关节炎的患病状况。方法按全国行政区划系统，选择六个流调中心：石家庄市、哈尔滨市、上海市、广州市、成都市和西安市。调查对象为年龄40岁及以上汉族男女一般人群。按分层、多阶段、整群随机抽样的原则进行抽样，样本数均为1000人，城乡各半、男女各半。原发性骨关节炎诊断标准采用美国风湿病协会1995年修订的诊断标准，调查部位为双膝、双手、颈椎和腰椎。结果共完成调查表6218份，获取x线资料5334份。六个流调中心40岁以上人群原发性骨关节炎的总体患病率为46．3％（2877／6218）；男性为41．6％（1212／2916），女性为50．4％（1665／3302）。不同年龄段原发性骨关节炎患病率分别为：40--49岁患病率30．1％（646／2145），50-59岁患病率48．7％（1086／2230），60-69岁患病率62．2％（754／1213），70岁以上患病率62．1％（391／630）。城乡原发性骨关节炎患病率分别为：城市45．6％（1472／3225），农村46．9％（140512993）。不同部位患病率分别为：颈椎23．6％（1468／6218），腰椎29．4％（1829／6218），双膝15．6％（972／6218），双手7．8％（484／6218）。结论基于六大行政区划的中国40岁以上人群原发性骨关节炎总体患病率为46．3％，呈现随年龄增长而增高的趋势。女性患病率高于男性，城市与农村人口患病率无差异。Objective To investigate the status of primary osteoarthritis in the population aged 40 years and over in Chi- na. Methods Six centers were selected from China which are Shijiazhuang, Harbin, Shanghai, Guangzhou, Chengdu and Xi＇an. The objective population of study included general population of Han nationality aged 40 years and over. In every center, 1 000 people were sampled according to the principles of hierarchy, multistage and cluster random sampling; and the urban and rural ar- eas as well as male and female accounted for half ratio respectively. For the diagnostic criteria of primary osteoarthritis, the diag- nostic criteria which were revised by American Society of Rheumatism in 1995 was applied. All joints of knee, hand, cervical and lumbar spine were included. Results Under the uniformed inclusion criteria and quantitative index, 6 218 questionnaires and 5 334 sample X-ray films were valid. The prevalence rate of primary osteoarthritis was 46.3% （2 877/6 218）, 41.6% （1 212/2 916） in male population and 50.4% （1 665/3 302） in female population. In four different age stages, the prevalence rate of 40-49 years was 30.1% （646/2 145）, 50-59 years 48.7% （1 086/2 230）, 60-69 years 62.2% （754/1 213） and 70 years and over was 62.1% （391/ 630）. The prevalence of OA in urban and rural areas was 45.6% （1 472/3 225） and 46.9% （1 405/2 993） respectively. The prevalence of OA in cervical spine was 23.6% （1 468/6 218）, lumbar spine 29.4% （1 829/6 218）, bilateral knee joints 15.6% （972/6 218） and hand joints 7.8% （484/6 218）. Conclusion Based on the investigation of six administrative regions in China, the total preva- lence rate of primary osteoarthritis was 46.3% and there was an increasing trend with aging. The prevalence rate of female population was higher than that of male population and there was no statistical difference between urban and rural population.

关 键 词：骨关节炎 患病率 流行病学研究 中国 

分 类 号：R684.3[医药卫生—骨科学]