联合检测ICTP、抗CCP抗体和RF在未分化关节炎向类风湿关节炎转化的预测价值  

The clinical predictive value of combined detection of ICTP,anti-CCP and RF in the transformation from undifferentiated arthritis to rheumatoid arthritis

作　　者：关晓东[1] 吴宇芳[2] 陈少莹[2] 朱学海[2] 曾丽萍[3] 邹原方[1] 梁翔[1] 唐杏明[1] 苏晓燕[1] 陈丽莉[2] 

机构地区：[1]中山大学附属东华医院肾内风湿科,广东东莞523110 [2]中山大学附属东华医院检验科,广东东莞523110 [3]中山大学附属东华医院统计室,广东东莞523110

出　　处：《重庆医学》2015年第34期4787-4789,共3页Chongqing medicine

基　　金：东莞市科技计划基金资助项目(201210515046246)

摘　　要：目的 探讨联合检测血清Ⅰ型胶原吡啶交联终肽（ICTP）、抗环瓜氨酸肽（CCP）抗体和类风湿因子（RF）在未分化关节炎（UA）转化为类风湿关节炎（RA）的临床预测价值。方法 对192例UA患者随访12个月,采用酶联免疫吸附法检测ICTP和CCP抗体,免疫比浊法检测RF。结果 单一检测指标阳性与UA转化为RA的关联强度中以CCP抗体最高,其相对危险度（RR）及95%可信区间为50.52（18.849-135.397）;其次是ICTP,其RR及95%可信区间为29.77（12.253-72.348）;ICTP和CCP抗体都为阳性的UA转化为RA的转化率为93.33%;ICTP、CCP抗体和RF共3项指标都为阳性的UA转化为RA的转化率为100%。结论 ICTP和CCP抗体的出现是UA患者发生RA的高危因素;ICTP、CCP抗体和RF联合检测阳性对UA向RA分化发展具有预测价值。Objective To investigate the clinical predictive value of combined detection of serum pyridinoline cross-linked carboxyterm inal telopeptide of Type I Collagen（ICTP）,anti-cyclic citrullinated peptide antibody （anti-CCP） and rheumatoid factor（RF）in the transformation from undifferentiated arthritis（UA） to rheumatoid arthritis（RA）. Methods I92 patients with UA who were followed up for a year were enrolled into the investigation. ICTP and anti-CCP were measured by ELISA, RF was meas- ured by the rate scatting immunity method. Results Anti-CCP was the best single antibody to evaluate the transformation from UA to RA, with risk ratio （RR）and 95 % CI was 50. 52 （18. 849-135. 397）, the second was ICTP, with RR and 95% CI was 29.77 （12. 253-72. 348）. 93.33% patients who had the positive of ICTP and anti-CCP transform from UA to RA. 100% patients who had the positive of ICTP, anti-CCP and RF transform from UA to RA. Conclusion The presence of anti-CCP and ICTP are the significant risk factor for RA. The combined detection indexes had the better predictive value in progression to RA in patients with UA.

关 键 词：类风湿因子 关节炎 类风湿 Ⅰ型胶原吡啶交联终肽 抗环瓜氨酸肽抗体 

分 类 号：R593.22[医药卫生—内科学]