人类长链非编码RNA相关SNP鉴定与功能预测的研究进展  

Research Progress of the Human Long Non-coding RNA Related SNP Identification and Function Prediction

作　　者：龚静[1] 柳纯洁 缪小平[1] 郭安源[2] 

机构地区：[1]华中科技大学公共卫生学院,武汉430030 [2]华中科技大学生命科学与技术学院,武汉430074

出　　处：《生物技术通报》2015年第11期27-34,共8页Biotechnology Bulletin

摘　　要：长链非编码RNA(lnc RNA)是一类长度大于200个核苷酸,且不表现出任何蛋白质编码潜能的RNA。最新研究表明,lnc RNA广泛地参与动植物的生长发育及疾病的发生发展等各种生物学过程,具有类型多、数量大且作用范围广等特点。目前对于lnc RNA的发现、预测方法、功能及与疾病的关系已有了一系列报道。主要对lnc RNA相关SNP文献进行综述,并对lnc RNA相关SNP的鉴定与功能预测方法进行介绍。对其中涉及的生物信息学方法及相应的数据库进行全面综述,旨在为lnc RNA研究提供新的思路,对复杂疾病的预测、诊断和治疗提供新的依据。Long non-coding RNA（lnc RNA）is a class of RNA, whose length is greater than 200 nucleotides and it does not show any protein-coding potential. The latest research shows that lnc RNA plays function widely in the development of plants and animals, as well as in various diseases. There have been a series of reports on the discovery, prediction method, function study of lnc RNA. Here, we reviewed the study of lnc RNA related SNPs, including their identification and functional prediction. A comprehensive review of the bioinformatics methods and databases about the lnc RNA related SNP was provided. These reviews may help to provide a new point of view for lnc RNA research and a hint for the prediction, diagnosis and treatment of complex diseases based on lnc RNA.

关 键 词：长链非编码RNA 生物信息学 单核苷酸多态性 数据库 

分 类 号：R346[医药卫生—基础医学] Q811.4[生物学—生物工程]