抗菌药物对肠球菌属细菌体外抗菌活性  

In vitro activity of antimicrobial agents against Enterococcus spp.

作　　者：戈伟[1] 张霄霄[1] 汪定成[1] 邵海连[1] 李颖[1] 杨铭[1] 程芝[1] 苏博[1] 范明乐 范珊红[1] 

机构地区：[1]第四军医大学唐都医院,陕西西安710038

出　　处：《中国感染控制杂志》2015年第11期753-756,共4页Chinese Journal of Infection Control

摘　　要：目的了解抗菌药物对某院临床分离肠球菌属细菌的体外抗菌活性。方法对2013年6月—2014年7月该院临床各科室送检标本分离的188株肠球菌属细菌进行细菌鉴定及药物敏感试验。结果 188株肠球菌属细菌其中屎肠球菌119株、粪肠球菌60株、鸟肠球菌9株,主要分布在尿和血标本,分别占34.57%和19.15%。未检出对达托霉素及利奈唑胺耐药的肠球菌属细菌;屎肠球菌对万古霉素的耐药率为1.68%,对青霉素、氨苄西林、高浓度庆大霉素、红霉素、左氧氟沙星的耐药率均>70%;除四环素外,粪肠球对其他抗菌药物的耐药率均低于屎肠球菌,粪肠球对青霉素、氨苄西林耐药率较低,分别为16.67%,13.33%。结论达托霉素对该院肠球菌属细菌具有良好的抗菌效果。Objective To investigate in vitro activity of antimicrobial agents against Enterococcus spp . isolated from clinic specimens in a hospital.Methods 188 Enterococcus spp . isolates from specimens sent by clinic depart-ments in June 2013-July 2014 were identified and performed antimicrobial susceptibility testing.Results Of 188 En-terococcus spp . isolates,119 were Enterococcus faecium （E.faecium）,60 were E.faecalis ,and 9 were E.avium, these strains were mainly isolated from urine （34.57%）and blood specimens （19.15% ）.No daptomycin and linezolid-resistant strain was detected;resistant rates of E.faecium to vancomycin was 1 .68%,to penicillin, ampicillin,high concentration gentamycin,erythromycin,and levofloxacin were all 〉 70%;except tetracycline, resistant rates of E.faecalis to the other antimicrobial agents were all lower than E.faecium,resistant rates of E. faecalis to penicillin and ampicillin were 16.67% and 13.33% respectively.Conclusion Daptomycin has high activity against Enterococcus spp . in this hospital.

关 键 词：肠球菌属 达托霉素 抗菌药物 抗药性 微生物 合理用药 

分 类 号：R378[医药卫生—病原生物学]