阿托品不同给药途径救治有机磷中毒的疗效对比研究  

Comparativ e Study on the Efficacy of Different Administration Routes of Atropine for Treatment of Organic Phosphorus Poisoning

作　　者：何日德[1] 

机构地区：[1]顺德第一人民医院附属杏坛医院,佛山528325

出　　处：《北方药学》2015年第12期119-120,共2页Journal of North Pharmacy

摘　　要：目的：探讨阿托品不同给药途径救治有机磷中毒的疗效。方法：选择我院2012年3月~2015年3月收治的78例急性有机磷农药中毒患者的临床资料进行回顾性分析,按给药途径分为两组,对照组患者先微量泵持续静脉输注阿托品,再行间歇静脉推注;观察组患者先行间歇静脉推注阿托品,达阿托品化后再采用微量泵持续静注。观察两组患者阿托品化时间、用量以及住院时间,比较两组临床治愈率和并发症发生率。结果：观察组的阿托品化时间、用量以及住院时间显著低于对照组;观察组患者的治愈率高达97.50%（39/40）,并发症发生率低至7.50%（3/40）,均显著优于对照组的81.58%（31/38）、34.21%（13/38）,差异具有统计学意义（P〈0.05）。结论：采用阿托品人工静脉推注,待患者阿托品化后再予以微量泵给药,不但起效速度快,临床疗效显著,而且并发症发生率低,值得在临床上推广。Objective：To explore the efficacy of different administration routes of atropine for treatment of organic phosphorus poisoning. Methods：78 patients with organic phosphorus poisoning were selected from 2012 May to 2015 May in our hospital for retrospectively analyzed and were divided into two groups for according to different administration routes.The control group were first treated with continuous intravenous infusion and then treated with artificial intermittent intravenous injection;Whilie the observation group were first treated with artificial intermittent intravenous injection,then treated with continuous intravenous infusion after atropine. Observed the differences of the two groups patients such as atropine time,dosage of atropine and length of hospital stay.Compared the clinical cure rate and the incidence of complications in the two groups.Results：The atropine time,dosage of atropine and length of hospital stay in the observation group were significantly lower than those in the control group;And the cure rate in the observation group was 97.50%（39/40） and the complication rate was 7.50% （3/40）,significantly better than the 81.58% （31/38）,34.21% （13/38）which difference was statistically significant （P〈0.05）.Conclusions： Use the artificial intermittent intravenous injection first and use the continuous intravenous infusion after atropine noy only has a fast onset with obvious curative effect,but also the incidence of complications is low which should be introduced in clinical practice.

关 键 词：阿托品 给药途径 有机磷中毒 人工间歇 微量泵 

分 类 号：R595.4[医药卫生—内科学]