补体C5a抑制剂对大鼠油酸型急性肺损伤治疗的实验研究  

Experimental Study of C5a Alexin Inhibitor on Treatment Rat With Acute Lung Injury

作　　者：刘杨[1] 薛华[1] 

机构地区：[1]黑龙江省医院老年呼吸内科,哈尔滨150036

出　　处：《中国继续医学教育》2015年第31期31-32,共2页China Continuing Medical Education

摘　　要：目的研究补体C 5 a抑制剂在肺损伤治疗方面的作用。方法将Wistar大鼠分为对照组、致伤组和治疗组。治疗组经股静脉注射油酸后10 min,雾化吸入补体C 5 a抑制剂后对主要的观察指标进行分析。结果对照组的支气管肺泡灌洗液均无炎症、水肿发生;其他三组均有不同程度炎症、水肿,其中致伤组最为严重。致伤组、治疗组肺系数数值对比,致伤组最大,治疗组次之。结论补体C 5 a抑制剂可以保护由油酸导致的急性肺损伤。Objective To investigate the role of complement C 5 a inhibitors in the treatment of lung injury. Methods Wistar rats were divided into the control group, the injury group and the treatment group. The treatment group intravenous injection oleinic acid by femoral vein 10 minutes, analyzed the mainly observation index after atomization inhalation complement C 5 a inhibitors.Results The control group had no bronchoalveolar lavage fluid inflammation and edema, the other three groups have different levels of inflammation and edema, particularly in the injury group of the most serious. Compared the lung coefficient values of injury treatment group and the treatment group, the injury group largest, followed by treatment group.Conclusion Complement C 5 a inhibitors can protect lung injury caused by the oleic acid.

关 键 词：补体C 5 a抑制剂 急性肺损伤 支气管肺泡灌洗液 

分 类 号：R3[医药卫生—基础医学]