人巨细胞病毒感染与高血压的关系研究  

Relationship between human cytomegalovirus infections and high blood pressure

作　　者：苏怀勇[1,2] 鹿克风[1] 侯晓阳[1] 王勇[1] 李敏[1] 

机构地区：[1]山东大学附属省立医院心内科,山东济南250021 [2]山东省阳谷县人民医院心内科,山东阳谷县252300

出　　处：《中华医院感染学杂志》2015年第23期5354-5355,5358,共3页Chinese Journal of Nosocomiology

基　　金：山东省科技厅基金资助项目(2008BS5CAA7)

摘　　要：目的比较高血压患者群体与健康人群的人巨细胞病毒(HCMV)感染率及血浆中和抗体水平,探讨HCMV感染率与高血压的关系,为预防和治疗高血压提供临床依据。方法选取2013年12月-2014年12月在医院接受治疗的60例高血压患者作为观察组,同期选取60名健康体检者作为对照组,比较两组受试者临床资料,数据采用SPSS 19.0软件进行统计分析。结果 HCMV的阳性率观察组为78.33%、对照组28.33%,观察组HCMV UL93DAN、HCMV IgG及HCMV IgM阳性率分别为71.67%、70.00%及41.67%,对照组分别为55.00%、56.67%及3.33%;HCMV特异性中和抗体检测观察组集合滴度为37.55±20.06,对照组集合滴度为59.69±24.32;各项指标结果对照组均优于观察组,其中HCMV、HCMV UL93DNA及HCMV IgG的结果比较,差异有统计学意义(P<0.05)。结论高血压患者HCMV感染率显著高于健康人群,特异性中和抗体水平降低,说明HCMV体液免疫状态低下,人巨细胞病毒与高血压显著相关。OBJECTIVE To compare the HCMV infection rates and plasma neutralizing antibody levels in patients with high blood pressure and healthy people and to discuss the relationship between HCMV infection rate and high blood pressure, so as to provide clinical basis for the prevention and treatment of high blood pressure. METHODS Totally 60 cases of high blood pressure patients admitted from Dec. 2013 to Dec. 2014 were chosen as observation group. In the same period, 60 healthy people were chosen as control group. The clinical data of the two groups were compared. All data were statistically analyzed by SPSS 19.0. RESULTS The observation group had the HC- MV positive ratio of 78.33%, while the control group got 28. 33%. The positive rates of HCMV UL93DAN, HCMV IgG and HCMV IgM of the observation group were 71.67%, 70.00% and 41.67% respectively, while 55.00%, 56.67% and 3.33% respectively of the control group. In HCMV specific neutralizing antibody tests, the average geometric drop degree of the observation group was （37.55±20.06）, it was （59.69±24.32） in the control group. For each index, the results of the control group were better than the observation group, and the differences among HCMV, HCMV UL93DNA and HCMV IgG levels were significant （P〈0.05）. CONCLUSION The HCMV infection rate of the high blood pressure group is significantly higher than that of healthy group with lowered specific neutralizing antibody levels, which shows that HCMV humoral immunity is weak and human cy- tomegalovirus is significantly associated with hypertension.

关 键 词：高血压 人巨细胞病毒 血浆中和抗体 

分 类 号：R373[医药卫生—病原生物学]