梅毒患者医院感染病原菌分布与血清学变化  

Pathogen distribution and serological changes of nosocomial infections in syphilitic patients

作　　者：虞玲[1] 隋俊[1] 黄菁[1] 华云晖[2] 

机构地区：[1]南京市第二医院检验科,江苏南京210003 [2]南京市第二医院性病科,江苏南京210003

出　　处：《中华医院感染学杂志》2015年第23期5356-5358,共3页Chinese Journal of Nosocomiology

基　　金：江苏省卫生厅重点基金资助项目(JW-20120372)

摘　　要：目的探讨中晚期梅毒患者医院感染的常见病原菌分布及血清学改变,为临床诊治提供参考依据。方法选取2009年4月-2014年4月医院收治的中晚期梅毒患者213例,将其中发生医院感染患者109例作为观察组,未发生医院感染患者104例作为对照组;取两组患者血液进行实验室检查,对其临床资料进行比较,数据采用SPSS 13.0软件进行统计分析。结果 109例医院感染患者共检出病原菌138株,以革兰阳性菌为主,共86株占62.32%;对照组患者IL-2、IL-10和IL-12分别为(97.15±10.54)(122.53±11.27)ng/L和(83.76±8.95)ng/L,观察组患者分别为(108.20±11.09)(117.04±9.27)ng/L和(63.81±6.19)ng/L,两组比较差异有统计学意义(P<0.05),两组患者IL-10水平差异无统计学意义。结论引起中晚期梅毒患者医院感染的病原菌以革兰阳性菌为主,经验性用药时可以此作为参考;而医院感染的患者与其他中晚期梅毒患者相比血清学检查存在差异,可以作为诊断参考。OBJECTIVE To investigate common bacterial distribution and serological changes of nosocomial infec- tions in patients with moderate and advanced syphilis, so as to provide reference {or clinical diagnosis and treat- ment. METHODS The 213 patients with moderate and advanced syphilis admitted and treated in the hospital dur- ing Apr. 2009 to Apr. 2014 were selected. Among them, the 109 patients who had nosocomial infections were set as the observation group and the rest 104 patients without infections as the control group. Blood specimens from the two groups were collected for laboratory test and clinical data of patients were compared. The software SPSS 13.0 was used for statistical analysis. REsuLTs From the 109 cases of nosocomial infections, 138 bacterial strains were detected, mainly including gram-positive bacteria in a total of 86 strains accounting for 62.32 %. IL-2, IL-10 and IL-12 were （97.15：k10.54） ng/L, （122.53±11： 27） ng/L and （83. 76±8.95） ng/L for the control group, and （108.20±11.09） ng/L, （117.04±9. 27） ng/L and （63.81±6. 19） ng/L for the observation group, the difference was significant （P〈0.05）. There was no significant difference in the IL-10 level between the two groups. CONCLUSION Gram-positive bacteria are dominant pathogens causing nosoeomial infections in syphilis patients, which can serve as a reference for empirical treatment. There are serological differences between the pa- tients with nosocomial infections and other patients with moderate and advanced syphilis, which can serve as a di- agnostic reference.

关 键 词：中晚期梅毒 医院感染 血清学改变 病原菌 

分 类 号：R378[医药卫生—病原生物学]