围术期抗菌药物应用对白内障患者术后感染的影响研究  

Influence of perioperative use of antibiotics on postoperative infections in cataract patients

作　　者：陆炯[1] 邢茜[1] 孟逸芳[1] 陶建军[1] 李健[1] 

机构地区：[1]常熟市第二人民医院眼科,江苏常熟215500

出　　处：《中华医院感染学杂志》2015年第23期5388-5389,5455,共3页Chinese Journal of Nosocomiology

基　　金：江苏省卫生厅基金资助项目(27418312)

摘　　要：目的研究围术期抗菌药物应用对白内障患者术后感染的影响,为白内障手术患者临床合理使用抗菌药物提供有价值的参考。方法将2013年6月-2014年5月医院1 765例患者随机分为局部用药组与联合用药组,局部用药组患者881例,采用局部应用抗菌药物的方法;联合用药组患者884例,采用局部联合全身应用抗菌药物的方法;对比两组患者细菌培养阳性率,术后感染率及应用抗菌药物费用、住院费用。结果局部用药组患者细菌培养阳性124例阳性率14.1%,术后感染2例感染率为0.2%;联合用药组细菌培养阳性126例阳性率14.2%,术后感染2例感染率为0.2%,两组患者培养阳性率与术后感染率比较差异无统计学意义;与联合用药组比较,局部用药组患者的抗菌药物费用和住院费用显著减少、住院时间显著缩短,差异有统计学意义(P<0.05)。结论白内障手术患者围术期局部与局部联合全身应用抗菌药物均能够有效预防患者术后感染,但局部用药患者的抗菌药物费用和住院费用显著减少,住院时间显著缩短。OBJECTIVE To observe the influence of perioperative use of antibiotics on postoperative infections in cataract patients so as to provide guidance for reasonable clinical use of antibiotics. METHODS A total of 1 765 pa- tients who were treated in the hospital from Jun 2013 to May 2014 were enrolled in the study and randomly divided into the topical administration group with 881 cases and the combined administration group with 884 cases. The topical administration group was treated with topical use of antibiotics, while the combined administration group was given the topical administration combined with systemic use of antibiotics. The positive rate of bacterial cul- ture, incidence of postoperative infections, cost of antibiotics, and hospitalization cost were compared between the two groups of patients. RESULTS The bacterial culture showed positive in 124 cases of the topical administration group, with the positive rate of 14.1%, and 2 cases had postoperative infections, with the infection rate of 0.2 % the bacterial culture showed positive in 126 cases of the combined administration group, with the positive rate of 14.2 %, and 2 cases had postoperative infections, with the infection rate of 0.2% ; there was no significant differ- ence in the positive rate of culture or the incidence of postoperative infections between the two groups of patients. The cost of antibiotics and hospitalization cost of the topical administration group were significantly less than those of the combined administration group, and the length of hospital stay of the topical administration group was sig- nificantly shorter than that of the combined administration group （P〈0.05）. CONCLUSION Both the perioperative topical administration and the topical administration combined with systemic use of antibiotics can effectively pre- vent the postoperative infections in the cataract patients, treated with topical administration cost significantly less, while the antibiotics and hospitalization of the patients with the length of hospital stay

关 键 词：围术期 药物 白内障 术后感染 住院时间 费用 

分 类 号：R978.1[医药卫生—药品]