晚期鼻咽癌患者同步放化疗治疗医院感染分析  

Prevalence of nosocomial infections in advanced nasopharyngeal carcinoma patients undergoing concurrent radiochemotherapy

作　　者：杨黎[1] 邓嘉虹[1] 戚本明[1] 任钢[1] 陈卿源 

机构地区：[1]云南省第一人民医院耳鼻喉科,云南昆明650032 [2]云南省罗平县中医医院耳鼻喉科,云南罗平县655800

出　　处：《中华医院感染学杂志》2015年第23期5459-5461,共3页Chinese Journal of Nosocomiology

基　　金：云南省卫生厅基金资助项目(2010W-11-3-007-03)

摘　　要：目的调查与分析晚期鼻咽癌(NPC)患者同步放化疗的医院感染情况,为临床抗感染治疗提供依据。方法选取2010年1月-2014年12月接受同步放化疗治疗的局部晚期NPC患者100例作为研究对象,对其医院感染情况、感染部位及病原体分布等进行分析;采用SPSS13.0统计软件进行统计分析。结果 100例晚期NPC患者中有78例发生了医院感染,感染率为78.00%,男性患者的医院感染率显著高于女性患者,两者差异有统计学意义(P<0.05);在治疗过程中共发生感染101例次,感染部位以鼻咽及口咽部黏膜为主,占92.08%;78例感染患者中共检出病原体48株,其中,以革兰阴性菌、真菌检出率最高,分别占58.33%、29.17%。结论晚期NPC患者在同步放化疗治疗过程中易发生医院感染,其感染部位和病原体分布均具有一定的特点,临床医师应对患者的高危因素和感染情况给予高度重视,采取有效的干预措施预防和控制医院感染的发生。OBJECTIVE To investigate the prevalence of nosocomial infections in the patients with advanced naso- pharyngeal carcinoma undergoing the concurrent radiochemotherapy so as to provide guidance for clinical treatment of the infections. METHODS A total of 100 patients with local advanced nasopharyngeal carcinoma who received the concurrent radiochemotherapy from Jan 2010 to Dec 2014 were recruited as the study objects. The incidence of nosocomial infections, infection sites, and distribution of pathogens were observed, and the statistical analysis was performed with the use of SPSS13.0 software. RESULTS Of 100 patients with advanced nasopharyngeal carcino- ma, 78 cases had the nosocomial infections, with the infection rate of 78.00%. The incidence of nosocomial infec- tions was significantly higher in the male patients than thet in the female patients （P〈0.05）. Totally 101 case- times of patients had the infections during the treatment, of whom 92.08% had the nasopharyngeal and oropha- ryngeal mucosa infections. A total of 48 strains of pathogens were isolated from the 78 patients with infections, of which 58.33% were gram-negative bacteria, and 29.17% were fungi. CONCLUSION The patients with advanced nasopharyngeal carcinoma are prone to have infections during the concurrent radiochemotherapy. The infection sites and distribution of pathogens show certain characteristics. It is necessary for the clinicians to pay great atten- tion to the high risk factors and the prevalence of infections and take effective interventions to the control of the nosocomial infections.

关 键 词：晚期 鼻咽癌 同步放化疗 医院感染 病原体 分布 

分 类 号：R181.32[医药卫生—流行病学]