头孢类抗生素残留检测方法及环境风险评估研究  

Detection Method and Environmental Risk Assessment of Cephalosporin AntibioticsResiduals

作　　者：王伟华 张万峰 

机构地区：[1]哈尔滨市环境监测中心站,黑龙江哈尔滨150076

出　　处：《环境科学与管理》2015年第11期144-146,共3页Environmental Science and Management

摘　　要：基于固相萃取-超高效液相色谱/电喷雾离子源/三重四级杆串联质谱技术,建立了水中头孢唑林和头孢呋辛的测试方法。目标物的检出限分别为5 ng/L和2 ng/L。在0.5~50μg/L范围内线性良好（r〉0.990）。利用该技术,检测一污水处理厂的入口水、出口水和入河口的目标物残留,入口水的平均浓度分别为：34.3μg/L和27.7μg/L,出口水的平均浓度分别为1.19μg/L和1.27μg/L,入河口的平均浓度分别为0.11μg/L和0.05μg/L。风险商值法评估入河口中残留的头孢呋辛为高风险等级。Based on solid extraction-ultra performance liquid chromatography-electrospray ionization-tandem mass spectrometyr（ SPE-UPLC-ESI / MS / MS）,a testing method for cefazolin and cefuroximein water was established. The detection limits of samples were 5ng / L and 2ng / L respectively. The correlation coefficient of the calibration curve was good（ r 〉0. 990）. With this method,theresiduals in the influent,effluent of a wastewater treatment plant and the estuarywere tested. Their average concentrations in influent were 34. 3 μg / L and 27. 7 μg / L,in the effluent were 1. 19 μg / L and 1. 27 μg / L,and in the estuary were0. 11 μg / L and 0. 05 μg / L,respectively. Risk quotient method was utilized to evaluate the environmental risk of these two antibiotics in the estuary,and cefuroxime was at high risk level.

关 键 词：头孢类抗生素 SPE-UPLC/MS/MS 环境风险评价 

分 类 号：X830.2[环境科学与工程—环境工程]