新生儿病理性黄疸的预防干预时间窗探讨  

Investigation of the prevention and intervention time window in pathological jaundice newborn

作　　者：海冬[1] 王岩[1] 宋力艳 王彩芳[1] 邸菁华[1] 

机构地区：[1]河北省唐山市开滦总医院儿科,063000

出　　处：《蚌埠医学院学报》2015年第11期1534-1536,共3页Journal of Bengbu Medical College

摘　　要：目的:探讨早期干预对新生儿病理性黄疸的预防效果。方法:对2012年3月至2014年12月分娩的302例足月新生儿脐静脉血进行肝功能检测,并分别在生后24 h、48 h及72 h给予脐血总胆红素浓度>50.1μmol/L或脐血总胆汁酸测量值>11.295μmol/L的新生儿进行提早干预治疗。结果:干预组新生儿病理性黄疸的发生率为23.65%,明显低于对照组的58.44%(P<0.01)。生后24 h干预组和生后48 h干预组及72 h干预组新生儿病理性黄疸发生率差异均无统计学意义(P>0.05)。结论:脐血总胆红素浓度>50.1μmol/L或脐血总胆汁酸测量值>11.295μmol/L的新生儿于生后进行干预治疗能有效预防病理性黄疸,值得临床推广。Objective： To investigate the preventive effects of the early intervention in newborn pathological jaundice. Methods： The liver function data of umbilical venous blood in 302 full-term newborns were measured from March 2012 to December 2014. The early intervention treatment in newborns with total bilirubin higher than 50. 1 μmol / L or total bile acid higher than 11. 295 μmol / L in umbilical cord blood were implemented after 24 h,48 h and 72 h of birth. Results： The incidence of the newborn pathological jaundice in early intervention（ 23. 65%） was lower than that in the nonintervention newborn（ 58. 44%）（ P〈0. 01）. The effects of 24 h,48 h and 72 h intervention group was not statistically significant（ P〉0. 05）. Conclusions： The invention after of birth in newborns with total bilirubin higher than 50. 1 μmol / L or total bile acid higher than 11. 295 μmol / L in umbilical cord blood can effectively prevent the pathological jaundice,which is worthy of promotion in clinic.

关 键 词：黄疸 新生儿 经皮测胆红素 脐血肝功能 预防干预 

分 类 号：R722.17[医药卫生—儿科]