4项指标联合检测在肾脏疾病早期诊断中的意义  

The diagnostic value of combined detection of four indexes in early diagnosis of nephropathy

作　　者：胡娟娟[1] 周铁成[1] 童开[1] 李小燕[1] 程晓东[1] 

机构地区：[1]第四军医大学西京医院检验科,陕西西安710032

出　　处：《国际检验医学杂志》2015年第23期3405-3406,共2页International Journal of Laboratory Medicine

摘　　要：目的探讨血清胱抑素C(Cys C)、视黄醇结合蛋白(RBP)、尿素氮(BUN)和肌酐(Cr)联合检测对肾脏疾病的早期诊断价值。方法选取2013年4月至2014年6月各类肾脏疾病住院患者230例,其中糖尿病肾病组130例,高血压肾病组100例;另选取200例体检健康者作为健康对照组;应用日立7180全自动生化分析仪检测血清Cys C、RBP、BUN及Cr水平。结果与健康对照组比较,糖尿病肾病组患者血清Cys C、RBP、BUN、Cr水平均升高,高血压肾病组患者血清Cys C、RBP水平升高,差异有统计学意义(P<0.05);而高血压肾病组患者血清BUN、Cr水平与健康对照组比较差异无统计学意义(P>0.05)。4项指标在肾脏疾病组的阳性率均高于健康对照组,4项指标联合检测肾脏疾病患者的阳性率(81.9%)高于单项检测。结论血清RBP、Cys C是早期肾功能损伤的敏感指标,和BUN、Cr联合检测可提高肾脏疾病早期诊断的灵敏度,具有重要的临床价值。Objective To explore the value of joint detection of serum cystatin C（Cys C）,retinol-binding protein（RBP）,urea nitrogen（BUN）and creatinine（Cr）in early diagnosis of nephropathy.Methods A total of 230 cases of inpatients with nephropathy form April 2013 to June 2014 were collected and divided into diabetic nephropathy group（130 cases）and hypertensive nephropathy group（100 cases）.Other 200 healthy individuals were collected as healthy control group.The serum levels of Cys C,RBP,BUN and Cr were detected by using the Hitachi 7180 automatic biochemistry analyzer.Results Compared with the healthy control group,the sertum levels of Cys C,RBP,BUN and Cr were significantly increased in the diabetic nephropathy group,and the serum levels of Cys C and RBP were significantly increased in hypertensive nephropathy group,there were statistically significant differences（P〈0.05）;while no statistically significant differences in serum levels of BUN and Cr were found between the hypertensive nephropathy group and healthy control group（P〈0.05）.Positive rates（81.9%）of the four indicators in the two nephropathy groups were higher than those in the healthy control group,and the positive rate of joint detection of the four indicators was higher than single detection in patients with nephropathy.Conclusion Serum RBP and Cys C are sensitive indicators for early renal damage,and combined with BUN and Cr could increase sensitivity of early diagnosis of nephropathy,which has significant clinical value.

关 键 词：胱抑素C 视黄醇结合蛋白 尿素氮 肌酐 联合检测 

分 类 号：R692[医药卫生—泌尿科学] R446.1[医药卫生—外科学]