Preparation and Quality Evaluation of Toltrazuril Nanoemulsion  

作　　者：Zhang Zhimei Deng Xuming Shen Zhiqiang Guo Shijin Fu Shijun 

机构地区：[1]College of Animal Science and Veterinary Medicine,Jilin University [2]Shandong Binzhou Animal Science and Veterinary Medicine Academy [3]Shandong Binzhou Research,Development and Promotion Center for Livestock and Poultry Propolis Vaccine [4]Shandong Lvdu Ante Veterinary Drug Co.,Ltd.

出　　处：《Animal Husbandry and Feed Science》2015年第5期314-316,共3页动物与饲料科学（英文版）

基　　金：Supported by Technological Innovation Project of Shandong Province(201220916001)

摘　　要：To determine the prescription and preparation method of toltrazuril nanoemulsion, we selected liquid paraffin, ethyl acetate, soybean oil, IPM and oleic acid as the oil phases, while RH-40, EL-40, OP-10, Tween-80 and Span-80 were the surfactants, and alcohol, 1,2-ropanediol, ispropanl, glycerol and PEG-400 were the co-surfactants. The best prescription was acquired through pseudo-ternary phase diagrams. The result showed that ethyl acetate, Tween-80 and 1,2-propanediol could facilitate the formation of nanoemulsion. The optimum prescription was surfactant：co-surfactant：oil phase：water phase =2：1：2：5, with the solubilizer of 10%. This prescription can prepare stable toltrazuril nanoemulsion.To determine the prescription and preparation method of toltrazuril nanoemulsion, we selected liquid paraffin, ethyl acetate, soybean oil, IPM and oleic acid as the oil phases, while RH-40, EL-40, OP-10, Tween-80 and Span-80 were the surfactants, and alcohol, 1,2-ropanediol, ispropanl, glycerol and PEG-400 were the co-surfactants. The best prescription was acquired through pseudo-ternary phase diagrams. The result showed that ethyl acetate, Tween-80 and 1,2-propanediol could facilitate the formation of nanoemulsion. The optimum prescription was surfactant：co-surfactant：oil phase：water phase =2：1：2：5, with the solubilizer of 10%. This prescription can prepare stable toltrazuril nanoemulsion.

关 键 词：Toltrasuril NANOEMULSION PREPARATION Quality evaluation 

分 类 号：S859.79[农业科学—临床兽医学]