奥美拉唑对氯吡格雷抗血栓药效的影响  

Effect of omeprazole on pharmacodynamics of clopidogrel

作　　者：葛鹏新 李鹏飞[2] 杜丽[2] 韩春光[2] 原美茹[2] 李慧[2] 马艳丽[2] 刘永学[1,2] 

机构地区：[1]安徽医科大学研究生学院,安徽合肥230032 [2]军事医学科学院放射与辐射医学研究所,北京100850

出　　处：《癌变．畸变．突变》2015年第6期477-479,共3页Carcinogenesis,Teratogenesis & Mutagenesis

摘　　要：目的:观察奥美拉唑对氯吡格雷抗血栓作用的影响。方法:将Wistar大鼠随机分为正常对照组、氯吡格雷组(10 mg/kg)、联合给药组(奥美拉唑40或80 mg/kg+氯吡格雷10 mg/kg)。各组均灌胃给药,对照组给予甲基纤维素(1 mL)。给药4 h后,通过测定血小板聚集率,大鼠动静脉型血栓质量,评价奥美拉唑对氯吡格雷抗血栓效果的影响。结果:通过对血小板聚集率的测定,确定了诱导剂ADP浓度为50μmol/L,阳性对照药氯吡格雷给药剂量为10 mg/kg;与对照组相比,10 mg/kg氯吡格雷组能明显抑制血小板聚集率,减少血栓形成;奥美拉唑80 mg/kg+氯吡格雷组血小板聚集率(43.7%)与氯吡格雷组(23.3%)比较显著升高(P<0.01),血栓质量亦显著增加(两组分别为41.45和21.31 mg,P<0.01)。结论:80 mg/kg奥美拉唑对氯吡格雷抗血栓产生竞争性抑制作用。OBJECTIVE：To observe the influence of omeprazole on the anti-thrombus effect of clopidogrel.METHODS：The experimental animals were randomly divided into three groups,control group,clopidogrel group,combination groupfomeprazole 40 or 80 mg/kg＋ clopidogrel 10 mg/kg）,control group（methyl cellulose 1 mL）.4 h after treatment,we measured the platelet aggregation rate,the quality of the thrombus in the arterio-venous shunt thrombosis model,and evaluated the antithrombotic effect of clopidogrel in rats.RESULTS：According to the results of platelet aggregation,we determined ADP concentration to be 50 μmol/L,and the dosage of clopidogrel 10 mg/kg.Compared with the control group,clopidogrel group showed significant inhibition of platelet aggregation,decreased the weight of thrombus.Omeprazole＋ clopidogrel group compared with clopidogrel group could significantly increase the rate of platelet aggregation（43.7%and 23.3%,respectively,P〈0.01）,and enhanced the weight of thrombus（41.45 and 21.31 mg,respectively,P〈0.01）.CONCLUSION：80 mg/kg omeprazole inhibited the antithrombotic effect of clopidogrel.

关 键 词：氯吡格雷 奥美拉唑 抗血栓 血小板聚集率 

分 类 号：R961[医药卫生—药理学]