柞蚕丝素/聚乳酸纳米纤维纱的制备及其生物学性能  

Preparation and biological properties of tussah fibroin / polylactic acid nanofiber yarns

作　　者：韩啟明 何建新[1,2] 谭卫琳 余志才[1,2] 邵伟力[3] 

机构地区：[1]中原工学院河南省功能性纺织材料重点实验室,河南郑州450007 [2]中原工学院纺织服装产业河南省协同创新中心,河南郑州450007 [3]天津工业大学纺织学院,天津300387

出　　处：《纺织学报》2015年第12期1-6,共6页Journal of Textile Research

基　　金：国家自然科学基金项目(51203196);NSFC-河南人才培养联合基金项目(U1204510);河南省教育厅科学技术研究重点项目(14A540003;14A540006);郑州市普通科技攻关项目(141PPTGG400)

摘　　要：为制备力学性能、可加工性、生物学性能良好的骨组织支架材料,利用双重共轭静电纺丝装置制备了4种不同成分比例的柞蚕丝素(TSF)/聚乳酸(PLA)纳米纤维纱线。分别通过SEM、红外光谱和细胞体外培养表征了纱线的形态、二次结构和生物学性能。结果表明:TSF质量分数为10%时,成纱条干均匀,毛羽较少,纱线中纤维直径较细,力学性能有所改善。细胞在体外培养不同时间后,TSF质量分数为10%的复合纳米纤维纱(PLTF)支架材料上的细胞具有较好的细胞形态和较多的细胞数量,因此PLTF支架材料能够作为合适的支架用于骨组织工程。Tussah fibroin（ TSF） / polylactic acid（ PLA） composite nanofiber yarns with different ratios of TSF to PLA were prepared to fabricate tissue scaffold with great mechanical properties, good processability and biological properties by a double conjugation static-spinning device. The scanning electronic microscopy（ SEM） and infrared spectroscopy（ FT-IR） and cell culture in vitro were used to characterize the morphology,secondary structure and biological properties of the yarns separately. The result indicates that the yarn with the ratio of TSF to PLA of 1 ∶ 9 gains smaller diameter,uniform evenness as well as less hairiness and better mechanical. After being cultured in vitro for different time,the yarn with the ratio of TSF to PLA of 1∶ 9 as tissue scaffold keep healthy and more cell counts to make the PLTF yarn suitable as appropriate scaffold for bone tissue engineering.

关 键 词：柞蚕丝素 聚乳酸 静电纺 纳米纤维纱 生物学性能 

分 类 号：TS102.1[轻工技术与工程—纺织工程]