内皮细胞损伤与心肾疾病相关性研究进展  

Correlation between Endothelial Cell Injury and Cardiovascular and Glomerular Disease

作　　者：韩福生[1] 杨美娟[2] 付滨[2] 

机构地区：[1]天津中医药大学研究生院,天津300073 [2]天津中医药大学第二附属医院肾病风湿科,天津300150

出　　处：《医学综述》2015年第23期4266-4269,共4页Medical Recapitulate

摘　　要：内皮细胞损伤可促使动脉粥样硬化和肾小球硬化的发生,内皮细胞损伤后形成过氧化低密度脂蛋白,经过一系列转化,最终形成粥样斑块。此外,系膜细胞和平滑肌细胞有相类似的生理功能和组织学特点,因此,内皮细胞的损伤与蛋白尿的发生密切相关,是肾小球硬化与动脉粥样硬化的始动环节;而两者机制的相似性也为寻找心肾疾病新的治疗靶点提供了线索和依据。Endothelial cell injury can promote the occurrence of atherosclerosis and glomerular sclerosis, since after endothelial cell injury overoxidized low density lipoprotein is formed which, through a series of transformation,develops into atheromatous plaque. In addition, mesangial cells and smooth muscle cells have similar physiological function and similar histological characteristics ,therefore, endothelial cell injury is closely related to the occurrence of proteinuria, which is the initiation of glomerular sclerosis and atherosclerosis;and the similarity of the two mechanisms also provideds clues and basis for looking for the new therapeutic targets of heart kidney disease.

关 键 词：内皮细胞损伤 蛋白尿 动脉粥样硬化 肾小球硬化 

分 类 号：R543.5[医药卫生—心血管疾病]