生物标志物在阻塞性睡眠呼吸暂停低通气综合征患者中的表达及意义  

The Expression and Significance of Biomarkers in Patients with Obstructive Sleep Apnea Hypopnea Syndrome

作　　者：郭巍[1] 张继华[1] 

机构地区：[1]云南省玉溪市人民医院呼吸内科,云南玉溪653100

出　　处：《医学综述》2015年第23期4328-4330,共3页Medical Recapitulate

摘　　要：阻塞性睡眠呼吸暂停低通气综合征是一种累及多系统、多器官损害的睡眠呼吸疾病,也是高血压、冠心病、动脉粥样硬化的独立高危因素。研究发现,患者慢性、间歇、反复的低氧血症所致的氧化应激、炎症反应是该疾病的主要病理生理改变。鉴于多导睡眠监测监测在基层医疗机构应用上的局限性,该文就一些生物标志物在该病患者中的表达进行综述,以期为该病的诊断、预后及临床疗效提供指导。Obstructive sleep apnea hypopnea syndrome is a kind of sleep respiratory disease involving multiple systems and organs, an independent high risk factor of high blood pressure, coronary heart disease, and atherosclerosis. The studies found that oxidative stress, inflammatory reaction caused by chronic, intermittent, repeated hypoxemia are the main pathophysiological changes of the disease. Given limitation of the polysomnography monitoring applications in primary medical institutions, here is to make a review of the expression of some biomarkers in patients with the disease, in order to guide the diagnosis, prognosis and clinical treatment of the disease.

关 键 词：阻塞性睡眠呼吸暂停低通气综合征 炎症反应 生物标志物 

分 类 号：R562.2[医药卫生—呼吸系统]