产后阴道菌群分布情况及乳杆菌活菌胶囊治疗的疗效  

Distribution of Vaginal flora after childbirth and efficacy of Live Lactobacillus capsules

作　　者：孙伟娟 

机构地区：[1]桐乡市妇幼保健院妇产科,浙江桐乡314500

出　　处：《中国微生态学杂志》2015年第12期1468-1470,共3页Chinese Journal of Microecology

摘　　要：目的探讨产后阴道菌群分布情况及乳杆菌活菌胶囊治疗的疗效。方法选择200例在桐乡市妇幼保健院分娩的产妇,在分娩前与分娩后6周检测产妇的阴道pH,并对阴道分泌物进行细菌培养。比较分娩前后产妇的阴道pH值、乳酸杆菌检出率。根据患者意愿将未患有阴道炎的产妇分为观察组与对照组,观察组予以乳杆菌活菌胶囊治疗,每天1次,每次1粒,连用10d,对照组不采取任何治疗,分别在分娩后3个月、6个月检测产妇的阴道pH,并对阴道分泌物进行细菌培养,比较两组阴道pH值及乳酸杆菌检出率的变化情况及细菌性与念珠菌性阴道炎的发病率,探讨乳杆菌活菌胶囊的疗效。结果分娩后6周产妇的阴道pH明显高于分娩前（P〈0.05）,而阴道乳酸杆菌检出率却低于分娩前（χ^2=73.87,P〈0.01）;产妇产后6周阴道炎患病率为11.0%,分娩后3个月与分娩后6个月,两组产妇阴道pH均较治疗前下降（P〈0.05或P〈0.01）,且观察组的下降幅度大于对照组（P〈0.05）,而两组产妇阴道乳酸杆菌检出率却较治疗前增多（χ^2=20.15、36.27,3.88、6.30,P〈0.05或P〈0.01）,且观察组的增多幅度大于对照组（χ^2=3.98、8.66,P〈0.05或P〈0.01）;分娩6个月后观察组细菌性与真菌性阴道炎发病率低于对照组（χ^2=24.79,P〈0.01）。结论产妇产后会出现阴道菌群紊乱,阴道pH上升,乳酸杆菌检出率下降,阴道炎患病率上升,采用乳杆菌活菌胶囊干预治疗能有效的平衡阴道菌群,减少产妇产后阴道炎的发生,是一种安全有效的治疗方法。Objective To discuss the distribution of vaginal flora after childbirth and the efficacy of Live Lactobacillus Capsules.Methods 200 parturient women without colpitis in our hospital were selected and divided into observation group and control group according to their personal will.The women in observation group were given live Lactobacillus capsules for 10 days,while those in control group received none.The vaginal pH values were detected three and six months after childbirth,and the vaginal secretions were cultured.The changes of vaginal pH values,detection rate of Lactobacilli and incidence of bacterial vaginosis（BV）and monilial vaginitis were compared between the two groups,and the efficacy of live Lactobacillus capsules was discussed.Results The vaginal pH values at 6months after childbirth were much higher than those before childbirth（P〈0.05）,while the detection rates of Lactobacilli were much lower（χ^2=73.87,P〈0.01）.The incidence rate of colpitis was 11.0% at 6months after childbirth.After treatment,the pH values of the parturient women in both groups declined at 3and 6months（P〈0.05 or P〈0.01）,with the declining rate in observation group higher than that in control group（P〈0.05）;The detection rates of Lactobacilli in both groups increased than those before treatment（χ^2=20.15,36.27,3.88 and 6.30,P〈0.05 or P〈0.01）,with the increasing value of observation group higher than that in control group（χ^2=3.98,8.66,P〈0.05 or P〈0.01）.The incidences of BV and monilial vaginitis in observation group at 6months after childbirth were lower than those in control group（χ^2=24.79,P〈0.01）.Conclusion Vaginal flora disorder may occur after childbirth,resulting in increasing vaginal pH,decreasing amount of Lactobacilli and rising morbidity rate of colpitis.Live Lactobacillus capsules can effectively regulate the balance of vaginal flora,and reduce occurrence rate of colpitis after childbirth,which is a safe and effective medical intervention.

关 键 词：产后阴道菌群 分布情况 乳杆菌活菌胶囊 

分 类 号：R711.31[医药卫生—妇产科学]