椎体骨质疏松骨折患者骨转换生化标志物的临床研究  

Clinical investigation of bone turnover makers in patients with postmenopausal osteoporotic vertebral fractures

作　　者：李国新[1] 袁忠治[1] 温健[1] 吴海龙[1] 汤晨逢[1] 

机构地区：[1]北京大学深圳医院脊柱外科,深圳518036

出　　处：《中国骨质疏松杂志》2015年第11期1357-1359,共3页Chinese Journal of Osteoporosis

摘　　要：目的探讨骨转换生化标志物对于绝经后骨质疏松椎体骨折的预测价值。方法 73例绝经后骨质疏松症患者分为骨折组及非骨折组,分别测定血清I型原胶原氨基端前肽(PINP)、I型胶原交联羧基末端肽(CTX)及骨密度并比较。结果绝经后骨质疏松骨折组患者的骨转换生化标志物水平明显高于非骨折组,其差异有显著性;而两者骨密度的差异无显著性。结论骨转换生化标志物可以作为预测绝经后骨质疏松骨折的重要指标。Objective To explore the predictive value of bone turnover markers on the osteoporotic vertebral fracture in postmenopa-usal patients. Methods Seventy-three patients with postmenopausal osteoporosis were divided into fracture group and non-fracture group. Procollagen type I N-terminal propeptide （P[NP）, carboxy terminal telopeptide of collagen type I （CTX） and bone mineral density （BMD） were determined and compared statistically. Results PINP and CTX in fracture group were significantly higher than those in non-fracture group. There was no significant difference of BMD between the two groups. Conclusion The bone turnover makers are important indicators for predication of the postmenopausal osteoporotic fracture.

关 键 词：骨转换生化标志物 骨质疏松骨折 绝经后 

分 类 号：R446.11[医药卫生—诊断学]