红花水提物中羟基红花黄色素A和脱水红花黄色素B在大鼠体内的药代动力学研究  

Study on pharmacokinetics of hydroxysafflor yellow A and anhydrosafflor yellow B from safflower extract in rats

作　　者：孙燕雯[1] 何昱[1] 刘文洪[1] 项海[1] 唐映红[1] 金湛[1] 

机构地区：[1]浙江中医药大学,杭州310053

出　　处：《中华中医药杂志》2015年第12期4287-4291,共5页China Journal of Traditional Chinese Medicine and Pharmacy

基　　金：国家自然科学基金项目(No.81373898);浙江省重点科技创新团队项目(No.2012R10044-06);浙江省卫生高层次创新人才培养工程项目~~

摘　　要：目的:探讨红花水提物中羟基红花黄色素A(HSYA)和脱水红花黄色素B(AHSYB)在大鼠体内的药代动力学特征。方法:红花水提物大鼠灌胃给药后,HPLC测定血浆中HSYA和AHSYB的含量,运用非房室模型经Win Nonlin 5.2软件求取药动学参数。结果:HSYA和AHSYB在大鼠体内的主要药动学参数Cmax、Tmax、t1/2z、AUC0→t和AUC0→∞分别为(4.14±0.42)和(1.87±0.29)μg/m L、30和20min、(96.78±9.32)和(83.46±7.53)min、(512.18±74.15)和(221.95±22.34)μg·min·m L-1、(584.78±86.58)和(242.42±23.27)μg·min·m L-1。结论:Cl、t1/2z等数据比较表明红花水提物中HSYA与AHSYB的药代动力学类似,两者在大鼠体内的吸收均较快,代谢也均较慢。Objective： To investigate the pharmacokinetic characters of hydroxylsafflor yellow A（HSYA） and anhydrosafflor yellow B（AHSYB） from safflower in rat bodies. Methods： Rats received gavage administration of extracts of sal ower, the contents of HSYA and AHSYB in plasma were determined by using high performance liquid chromatography（HPLC）, and the pharmacokinetic parameters were calculated by using non-compartment model and Win Nonlin 5.2 software. Results： The main pharmacokinetic parameters Cmax, Tmax, t1/2z, AUC0→t and AUC0→∞ of HSYA and AHSYB were（4.14±0.42） and（1.87±0.29） μg/m L, 30 and 20 min,（96.78±9.32） and（83.46±7.53） min,（512.18±74.15） and（221.95±22.34） μg·min·m L-1,（584.78±86.58） and（242.42±23.27） μg·min·m L-1, respectively. Conclusion： According to the values of Cl and t1/2z, HSYA and AHSYB had similar pharmacokinetics trend. The absorption of them within safflower extraction was relatively fast in rats, however the metabolism was slow.

关 键 词：红花 羟基红花黄色素A 脱水红花黄色素B 药代动力学 

分 类 号：R285.5[医药卫生—中药学]