张仲景方中茯苓量效关系的研究  

Research on dose-effect relationship of Indian bread in formulas of ZHANG Zhong-jing

作　　者：李敏[1,2] 何庆勇[1] 陈胤峰 王阶[1] 

机构地区：[1]中国中医科学院广安门医院,北京100053 [2]北京中医药大学,北京100029

出　　处：《中华中医药杂志》2015年第12期4311-4313,共3页China Journal of Traditional Chinese Medicine and Pharmacy

基　　金：科技部"重大新药创制"资助项目(No.2012ZX09102201-006);国家自然科学基金项目(No.81173166;No.81473561)~~

摘　　要：目的:探讨张仲景方中茯苓剂量与疗效的关系,为临床茯苓使用剂量提供参考。方法:使用Excel数据库,控制相异率在3%以下,由双人双机独立录入方剂名、药物配伍、主治病症、茯苓总剂量、煎煮后药液总容积、单次服药容积,并进行统计分析。结果:张仲景方中茯苓一次量为40、30、22.5、20、15、14、10.5、10、9、7.5、5、1.25g,以10、20g为界,将茯苓剂量分为小剂量、中剂量、大剂量段。其中,茯苓在小剂量段有5首方剂,在中剂量段有12首方剂,在大剂量段有6首方剂。茯苓一次量的区间甚为广泛,从1.25g到40g不等。茯苓使用频率较高的一次量集中在10g-20g,占张仲景方汤药中茯苓方剂的52%。结论:茯苓小剂量健脾渗湿、化痰止泻;中剂量利尿理气、宁心定悸;大剂量利水消肿、平胃止呕。建议将相关教材规定的茯苓剂量采用小剂量、中剂量、大剂量段的方式来描述,更有助于茯苓临床用药的细化和标准化。Objective： To explore the dose-effect relationship of Indian bread in formulas of ZHANG Zhong-jing, in order to provide references for the clinical application of Indian bread. Methods： Names of prescriptions, compatibility of medicines, total dosage of Indian bread, total volume of drugs after decocting and the volume of a single dose were entered into Excel database by two people with two computers separately with dissimilitude ration controlled under 3%, and then the data was analyzed. Results： The single doses of Indian bread in formulas of ZHANG Zhong-jing were 40, 30, 22.5, 20, 15, 14, 10.5, 10, 9, 7.5, 5, 1.25 g. The dosage more than 20 g was the high dosage, between 10 g and 20 g was middle dosage, and less than 10 g was low dosage. There were 5 formulas included low dosage Indian bread, 12 formulas included middle dosage Indian bread, and 6 formulas included high dosage Indian bread. The section of single dose of Indian bread had a wide distribution, which ranged from 1.25 g to 40 g. The single dose of Indian bread with high usage frequency focused on 10g-20 g, which accounted for 52% of ZHANG Zhong-jing＇s formulas including Indian bread. Conclusion： The effects of low dosage of Indian bread are reinforcing sleep and eliminating dampness, and dispersing phlegm and relieving diarrhea, the effects of middle dosage of Indian bread are dieresis, regulating qi, calming heart for relieving palpitation, and the effects of high dosage of Indian bread are inducing diuresis for removing edema and regulating stomach for preventing vomiting. It suggests that the dosage of Indian bread stipulated in relevant material would be described with low dosage, middle dosage and high dosage, which contributed to the standardization of drug application in clinic.

关 键 词：张仲景 方剂 茯苓 量效关系 

分 类 号：R222[医药卫生—中医基础理论]