不同基源郁金的比较药理研究  

Comparative study on pharmacological of different varieties of Radix Curcumae

作　　者：蒋浩[1,2] 宋军[1] 鄢良春[1] 邓居桥[1] 赵军宁[1] 

机构地区：[1]四川省中医药科学院,成都610041 [2]云南省药物研究所安全性评价中心,昆明650111

出　　处：《中华中医药杂志》2015年第12期4491-4494,共4页China Journal of Traditional Chinese Medicine and Pharmacy

基　　金：中医药行业科研专项项目(No.200807020)~~

摘　　要：目的:探讨不同基源郁金药理作用的差异。方法:采用二磷酸腺苷诱导血小板聚集法观察不同基源郁金抗血小板聚集作用;二甲苯致小鼠耳肿胀模型观察抗炎作用;α-萘异硫氰酸酯所致小鼠黄疸模型观察利胆退黄作用差异及兔离体十二指肠观察对平滑肌自发活动的影响。结果:黄丝郁金、温郁金、桂郁金、绿丝郁金均能明显抑制兔体内血小板聚集(P<0.05),4种郁金对二甲苯急性耳肿胀均无明显抑制作用;桂郁金能明显降低黄疸小鼠血清DBIL、TBIL及AST含量(P<0.05);温郁金兔对离体十二指肠自发运动表现出先兴奋后抑制的作用,而桂郁金为持续的增强作用(P<0.05,P<0.01),黄丝郁金、绿丝郁金在高浓度时对兔离体十二指肠自发运动有明显抑制作用(P<0.05,P<0.01)。结论:4种不同基源郁金药理作用谱有比较明显的差异。Objective： To explore the differences in pharmacological action of different varieties of Radix Curcumae. Methods： Platelet agglutination induced by adenosine diphosphate（ADP） was used to observe the anti-agglutination effect of different varieties of Radix Curcumae on platelet. The mice model of ear swelling induced by xylene was used to observe the effect of anti-inl ammation. The mice model of jaundice induced by alpha naphthyl isothiocyanates（ANIT） was used to observe the effect of promoting the function of gallbladder to treat jaundice. The rabbit duodenum in vitro was used to observe the impact on activity of smooth muscles. Results： The four kinds of Radix Curcumce could significantly inhibit platelet agglutination in rabbits induced by ADP（P〈0.05）. The four kinds of Radix Curcumae had no significant effect on the mice model of ear swelling induced by xylene. Curcuma kwangsiensis S. G. Lee et C. F. Liang could significantly decrease the contents of DBIL, TBIL and AST in mice model of jaundice（P〈0.05）. The effect of Curcurna wenyujin Y. H. Chen et C. Ling on the movement of duodenum showed the responses with initial excitation and later inhibition, Curcuma kwangsiensis S. G. Lee et C. F. Liang, however, showed a sustainability excitation（P〈0.05, P〈0.01）. Curcuma Longa L. and Curcurna phaeocaulis Val. could remarkably inhibit the movement of duodenum（P〈0.05, P〈0.01）. Conclusion： There are significant differences in pharmacological actions among the four kinds of Radix Curcumae.

关 键 词：郁金 血小板聚集 抗炎 黄疸模型 十二指肠 比较药理 

分 类 号：R285.5[医药卫生—中药学]