25羟维生素D、NT-proBNP与左心室肥厚的相关性研究  

Relationship Between Left-Ventricular Hypertrophy with 25-Hydroxy Vitamin D and NT-proBNP

作　　者：陈荣花[1] 张瑞荣[1] 王希柱[1] 宋巧凤[1] 刘婷婷[1] 魏民[1] 朱艳辉[1] 王晓玲[1] 张立杰[1] 

机构地区：[1]河北省唐山市人民医院心内科,河北唐山063000

出　　处：《医学临床研究》2015年第11期2188-2190,共3页Journal of Clinical Research

摘　　要：【目的】探讨25羟维生素 D[25‐（OH）D]、氨基末端‐B型脑钠肽前体（NT‐proBNP）与左心室肥厚（L V H ）的相关性。【方法】选取2010年1月至2014年12月本院收治的156例原发性高血压患者。依据左室质量指数（LVMI）增高标准（女性LVMI≥110 g／m2，男性 LVMI≥125 g／m2）将患者分为LVH组（ n ＝72）和非LVH组（ n ＝84），观察比较两组患者一般资料，并应用Logistic回归分析LVH相关危险因素。LVH组患者口服罗钙全，将其随机分为高剂量组和低剂量组，每组36例，高剂量组口服罗钙全05．μg ，低剂量组02．5μg ，于12周后观察比较两组患者的治疗效果。【结果】女性、收缩压（SBP）、心律失常、血红蛋白（Hb）、NT‐proBNP、25‐（OH）D均与高血压LVH相关。治疗前高剂量组和低剂量组LVMI、心律失常、Hb、NT‐proBNP比较均无显著性差异（均 P ＞00．5）；治疗后，两组LVMI和NT‐proBNP显著降低，Hb显著升高（ P ＜00．5），心律失常比例降低但无统计学意义（ P ＞00．5）。【结论】心律失常、NT‐proBNP、25‐（OH）D是高血压LVH的危险因素，而维生素D缺乏可引起LVH并加重其进展。Objective] To investigate the relationship between left‐ventricular hypertrophy with Vitamin D , NT‐proBNP ,and arrhythmia .[Method]The 156 cases of patients with primary hypertension in our hospital from January of 2010 to December of 2014 were divided into the left ventricular hypertrophy group （72 cases） and non‐left ventricular hypertrophy group （84 cases） according to left ventricular mass index （LVMI） .Patients in left ventricular hypertrophy group were again divided into the low dosage group and the high dosage group with 36 ca‐ses in each group .Patients in the low dosage group and high dosage group received calcitrol 0 2.5 ug and 0 5. ug ,re‐spectively [.Results]Sex ,SBP ,arrhythmia ,hemoglobin ,NT‐proBNP ,and 25‐hydroxy vitamin D were independ‐ent risk factors for patients with primary hypertension and left ventricular hypertrophy （ P 〈0 0.5 or P 〈0 0.1） . Before treatment ,there was no significant difference between LVMI ,arrhythmia ,hemoglobin ,NT‐proBNP ,and 25‐hydroxy vitamin D of low dosage group and high dosage group （ P 〉0 0.5） .After treatment ,LVMI and NT‐proBNP of both groups significantly decreased and hemoglobin significantly increased （ P 〈0 0.5） ,with no signifi‐cant change in arrhythmia （ P 〉0 0.5） .[Conclusion] Arrhythmia and NT‐proBNP were results of left ventricular hypertrophy whereas vitamin D deficiency could aggravate and further left ventricular hypertrophy .

关 键 词：羟基胆骨化醇类 利钠肽  脑 心律失常  心性 肥大  左心室 

分 类 号：R541[医药卫生—心血管疾病]