聚乙二醇功能化的N-杂环卡宾-膦Pd催化剂在水相中的Suzuki反应研究  

Study on PEG-functionlized N-heterocyclic Carbene-phosphine Palladium Catalyst for Suzuki Coupling-Reaction in Aqueous Phase

作　　者：贾莉[1] 

机构地区：[1]福建师范大学福建省高分子材料重点实验室,福建福州350007

出　　处：《合成化学》2015年第12期1158-1161,共4页Chinese Journal of Synthetic Chemistry

基　　金：国家自然科学基金资助项目(20971023)

摘　　要：以聚乙二醇(PEG)功能化的N-杂环卡宾-膦Pd为催化剂[Cat(n=15)],研究了Cat在水相中催化4-甲基溴苯(1)与苯硼酸(2)的Suzuki偶联反应。考察了PEG的种类及其用量,Cat的用量对Suzuki偶联反应的影响。结果表明:加入50%PEG-400作为共溶剂后,Cat在水相中催化Suzuki反应的催化活性与在二氧六环中相当。当Cat用量为0.1 mol%,于110℃反应3 h时,1的转化率接近100%;Cat用量为0.01 mol%,于110℃反应21 h,转化率为57%(即TON为5 700)。Cat重复使用一次后催化活性不变。Studies of PEG-functionlized N-heterocyclic carbene-phosphine palladium catalyst[Cat（ n = 15） ]for coupling 4-bromotoluene（ 1） with phenylboronic acid（ 2） in aqueous-phase have been carried out. Effects of PEG kinds and amount,Cat dosage on Suzuki coupling were investigateed.The results showed that 50% PEG-400 as co-solvent,the catalytic activities of Cat was similar with in1,4-dioxane,and the conversion of 1 was nearly 100% at 110 ℃ for 3 h at loading of 0. 1 mol%,and was 57% at 0. 01 mol% at 110 ℃ for 21 h（ TON 5 700）. It was found that the Cat can be recycled and reused once at loading of 0. 1 mol%.

关 键 词：N-杂环卡宾 膦 聚乙二醇 水相催化 PD催化剂 SUZUKI反应 

分 类 号：O623.615[理学—有机化学]