植物提取物对细菌毒力因子抑制作用研究进展  

Progress on Inhibitory Effects of Plant Extracts on Virulence Factors in Bacteria

作　　者：刘晓琳[1] 宋雪娇[1] 徐程程[1] 孙磊[1] 田春莲[1] 张德显[1] 刘明春[1] 

机构地区：[1]沈阳农业大学畜牧兽医学院,辽宁沈阳110866

出　　处：《动物医学进展》2015年第12期137-140,共4页Progress In Veterinary Medicine

基　　金：国家自然科学基金项目(31201954)

摘　　要：抗菌药物在防治细菌性疾病方面具有重要作用,但是抗生素的广泛使用而导致的耐药性给细菌性疾病的治疗带来了极大的困难。近年来,以毒力因子为作用靶部位的抗感染药物在控制细菌感染方面受到人们重视,特别是植物提取物对细菌毒力因子具有多方面的抑制作用而受到国内外研究学者的广泛关注。论文就植物提取物在抑制细菌内毒素、溶血素、肠毒素、神经氨酸酶以及与侵袭力相关的毒力因子方面的研究进展进行综述,以期为开发新型抗细菌性感染的植物成分提供理论基础。Although antimicrobial agents are essential in preventing and curing infections caused by bacteria,the resistance to these agents has become an increasingly widespread problem.Virulence factors have been discovered as innovative targets used for controlling bacterial infections,especially in terms of inhibiting the infections by various mechanisms.In this review,we mainly focused on the progress of plants extracts on inhibiting the virulence factors reported by researchers recently,including endotoxin,hemolysin,enterotoxin,neuramidinase and other virulence factors involving in infections,this will be benefit for the development of drugs in curing infections caused by bacteria.

关 键 词：植物提取物 毒力因子 细菌 抑制作用 

分 类 号：S859.79[农业科学—临床兽医学]