中国人群醛糖还原酶基因C-106T多态性与2型糖尿病肾病相关性的荟萃分析  

Association between C-106T gene polymorphisms of aldose reductase and diabetic kidney disease in Chinese with type 2 diabetes

作　　者：张并璇[1,2] 孔勤[2] 赵海玲[2] 李平[2,1] 

机构地区：[1]北京中医药大学研究生院,北京100029 [2]中日友好医院临床医学研究所免疫炎性疾病北京市重点实验室,北京100029

出　　处：《中日友好医院学报》2015年第6期352-357,共6页Journal of China-Japan Friendship Hospital

基　　金：国家"十二五"科技支撑计划项目(2013BAI02B04);科技部国际科技合作项目(2011DFA31860);国家自然科学基金重点项目(81130066)

摘　　要：目的:通过对相关研究文献的系统评价和荟萃分析,探讨中国人醛糖还原酶(AR)基因C-106T多态性与糖尿病肾病(DKD)易感性的关系。方法:系统检索中英文科技期刊数据库,收集中国人AR基因C-106T多态性与DKD易感性的相关研究,按纳入与排除标准筛选文献、提取资料并评价纳入研究的方法学质量。采用Stata12.0软件进行荟萃统计分析,并检测敏感性及发表偏倚。结果 :共4篇研究、2271例样本纳入分析,其中DKD组711例、对照组1560例。荟萃分析结果显示,中国人AR基因C-106T多态性与DKD显著相关,T等位基因携带者发生DKD风险显著升高[OR=1.58,95%CI(1.13,2.22),P=0.008]。显性遗传模型:OR=1.814,95%CI(1.197,2.748),P=0.005;共显性遗传模型:OR=1.744,95%CI(1.185,2.567),P=0.005。但由于纳入研究间样本量差距较大,存在一定发表偏倚。而敏感性分析显示去掉任何一项研究对合并OR值影响并不显著。结论:AR基因C-106T多态性与中国人DKD的发生存在一定相关性;T等位基因携带者可能存在更高的DKD发生风险。objective：To evaluate the association of aldose reductase （AR）C-106T gene polymorphism with the risk of diabetic kidney disease （DKD）in Chinese with type 2 diabetes,we conducted this meta-analysi.Meth- ods：Literatures were identified from PubMed,EMBASE,Cochrane Library,CBM,CNKI,Wangfang and VIP database on July 1,2015,and eligible reports were evaluated.Statal2.0 software was used to do the meta-anal- ysis,and the detection of sensitivity and publication bias.Results：Four studies and 2271 individuals were in- cluded in the final analysis.Significant association were found between AR C-106T gene polymorphism and susceptibility of DKD in patients with type 2 diabetes.T allele significantly increased the risk of the occur- rence of DKD [OR=1.58,95%CI（1.13,2.22）,P=0.008].As compared T allele with C allele,there were signifi- cant differences in the susceptibility both in dominant model [0R=1.814,95%CI （1.197,2.748）,P=0.005]and codominance model [0R=1.744,95%CI （1.185,2.567）,P=0.005].However, due to large sample size gap between the included studies,there was a publication bias.The sensitivity analysis showed that if any study removed, there was no influence on the pooled OR.Conclusion：The T allele of AR C-106T gene polymorphism may in- crease the susceptibility of DKD in Chinese with type 2 diabetes.

关 键 词：糖尿病肾病 醛糖还原酶基因 C-106T多态性 荟萃分析 

分 类 号：R587.2[医药卫生—内分泌] R692.9[医药卫生—内科学]