寡克隆区带检测在中枢神经系统疾病诊断中的应用  

Application of oligoclonal bands in the diagnosis of central nervous system diseases

作　　者：孟俊[1] 彭奕冰[1] 张冬青[2] 

机构地区：[1]上海交通大学医学院附属瑞金医院检验科,上海200025 [2]上海交通大学医学院上海市免疫学研究所,上海200025

出　　处：《检验医学》2015年第11期1157-1160,共4页Laboratory Medicine

基　　金：国家自然科学基金面上项目(31270963);上海市科委重点连续资助项目(10JC1408500);上海市科委生物医药领域科技支撑项目(14431903700);上海交通大学医学院附属瑞金医院优青项目(8003)

摘　　要：中枢神经系统(CNS)产生强免疫应答是某些自身免疫性神经系统疾病发生、发展的病理学基础,表现为脑脊液(CSF)中免疫球蛋白成分及含量的变化。CSF寡克隆区带(OCB)是数个B细胞系株(克隆)在CNS局部产生的特异抗体,是针对CNS内某些特定抗原的一种特异反应。CSF中OCB的出现往往高度提示有免疫球蛋白的鞘内合成。OCB对CNS疾病的诊断及鉴别诊断有一定的临床意义,尤其对多发性硬化症(MS)等中枢神经脱髓鞘疾病的辅助诊断价值越来越受到人们瞩目。The strong immune response produced by central nervous system （CNS） is the pathological basis on the occurrence and development of some autoimmune nervous diseases, characterized by immunoglobulin composition and content in cerebrospinal fluid（CSF）. The CSF oligoclonal bands（OCB） are the specific antibodies produced by several B-cefl strains（clone） located in CNS, which is a specific reaction for CNS. The presence of OCB in CSF often indicates that intrathecal immunoglobulin synthesis were produced in CNS. It has certain clinical significance to diagnose CNS diseases by OCB, especially for the diagnosis of CNS demyelinating diseases, like multiple sclerosis （MS）.

关 键 词：寡克隆区带 中枢神经系统 脑脊液 诊断 

分 类 号：R446.62[医药卫生—诊断学]