血清五聚素3浓度与急性非ST段抬高型心肌梗死患者预后的关系  

Correlation between serum concentration of pentraxin 3 and prognosis of patients with acute non-ST-segment elevation myocardial infarction

作　　者：彭程[1] 魏晓艳[1] 陈剑锋[2] 

机构地区：[1]武警湖北总队医院急诊科,武汉430061 [2]武警湖北总队医院心内科,武汉430061

出　　处：《岭南心血管病杂志》2015年第6期759-761,共3页South China Journal of Cardiovascular Diseases

摘　　要：目的研究血清五聚素3(pentraxin 3,PTX3)浓度与急性非ST段抬高型心肌梗死(non-ST-segment elevation myocardial infarction,NSTEMI)患者预后之间的关系。方法收集因胸痛(发病时间<4 h)就诊的确诊NSTEMI患者78例为NSTEMI组,冠状动脉造影提示正常者64例为对照组。所有患者检测血清PTX3、心肌肌钙蛋白I(c Tn I)浓度,超声心动图测定患者左心室射血分数(left ventricular ejection fraction,LVEF)及左心室舒张末期内径(left ventricular end-diastolic dimension,LVEDd)并进行组间比较。随访NSTEMI组主要心血管事件1年,分析血清PTX3浓度与其之间的关系。结果与对照组比较,NSTEMI组PTX3及肌钙蛋白I浓度明显升高,LVEDd增高显著,LVEF明显下降,差异有统计学意义(P<0.01;P<0.05)。血清PTX3浓度与肌钙蛋白I浓度呈正相关(r=0.8341,P<0.01),与LVEDD呈正相关(r=0.4468,P<0.05),与LVEF呈负相关(r=-0.4215,P<0.05)。对NSTEMI患者血清PTX3浓度对1年内的主要心血管事件发生之间的预测价值进行受试者工作特征曲线分析,结果具有统计学意义(P<0.05)。结论血清PTX3浓度升高对急性NSTEMI患者发生心功能不全有预测价值,可能提示主要心血管事件的发生风险。Objectives To investigate the correlation between serum concentration of pentraxin 3 （PTX 3 ） and prognosis of patients with acute non-ST-segment elevation myocardial infarction （NSTEMI）. Methods A total of 78 NSTEMI patients admitted to Corps Hospital with chest pain （time of onset〈4 h） were enrolled into NSTEMI group; 60 healthy subjects with normal coronary angiographic results were enrolled into control group. Serum concentrations of PTX3 and cardiac troponin I （cTnI） were measured. Echocardiography was performed to measure cardiac functional parameters including left ventricular ejection fraction （LVEF） and left ventricular end-diastolic diameter （LVEDd）. The differences between the two groups were compared. All the NSTEMI patients were followed up for 1 year to observe major adverse cardiovascular events （MACE）. Interrelationship between serum concentration of PTX3 and MACE was analyzed. Results Compared with control group, serum concentrations of PTX3 and cTnI in NSTEMI group were significantly higher, LVEDd increased but LVEF decreased obviously （P〈0.01 or P〈0.05）. Serum concentration of PTX3 was positively related to cTnI （r=0.8341 ,P〈0.01） and LVEDd （r=0.4468, P〈0.05）; while negatively related to LVEF （r=-0.4215,P〈0.05）. Receiver operator characteristic curve analysis indicated that serum concentration of PTX 3 in patients with NSTEMI and one-year MACE had a significant correlation （P〈0.05）. Conclusions Increased serum concentration of PTX 3 shows a predictive significance for cardiac dysfunction in patients with NSTEMI, indicating a risk of MACE.

关 键 词：心肌梗死 五聚素3 预后 

分 类 号：R542.22[医药卫生—心血管疾病]