斑点追踪成像技术评价糖尿病大鼠左心功能的研究  

Comparative study of speckle tracking echocardiography in evaluating left ventricular function in diabetic rat

作　　者：张梦珍[1] 刘晓颖[1] 江雪燕[1] 符永恒[1] 林秋雄[1] 麦丽萍[1] 陈秀云[1] 陈少贤[1] 祁周措[1] 杨敏[1] 

机构地区：[1]广东省人民医院(广东省医学科学院)医学研究部,广州510080

出　　处：《岭南心血管病杂志》2015年第6期849-852,共4页South China Journal of Cardiovascular Diseases

摘　　要：目的评价斑点追踪成像技术(speckle tracking imaging,STI)的速度、位移和形变(应变及应变率)在检测2型糖尿病大鼠左心功能的灵敏性和应用价值。方法雄性SD大鼠按照30 mg/kg给予链脲佐菌素尾静脉注射后喂以高脂饲料,期间检测空腹血糖(fasting plasma glucose,FPG)及2 g/kg葡萄糖溶液灌胃2 h后的血糖(plasma glucose 2 h,PG2 h),以确定大鼠2型糖尿病模型建立成功;建模6周后用STI检测左心室6个不同节段收缩期、舒张期径向和周向速度、位移、形变(应变和应变率),并比较其变化情况。结果建模3周后,8只测得FPG>7.0 mmol/L和(或)PG2 h>11.1 mmol/L的大鼠被纳入模型组。建模6周后,STI分析显示模型组左心室收缩期和舒张期部分节段的径向、周向速度和位移较对照组显著降低,差异具统计学意义(P<0.05)。但左心室6个不同节段的收缩期和舒张期径向、周向整体速度,收缩期和舒张期径向、周向整体位移与对照组相比,差异均无统计学意义(P>0.05);形变分析显示模型组舒张期各节段径向、周向应变及其6节段的整体径向和周向应变,收缩期、舒张期径向整体应变率较对照组显著降低,差异有统计学意义(P<0.05)。结论 STI能够在早期检测到2型糖尿病大鼠左心室心肌部分节段收缩及舒张功能受损,采用形变参数评估心功能比速度和位移更为灵敏。Objectives To study the application of velocity, displacement and deformation by speckle tracking imaging （STI） in evaluation of left ventricular function in type 2 diabetic rats. Methods Male SD rats were injected with 30 mg/kg streptozotocin through caudal vein and fed with high-fat diet. Fasting plasma glucose （FPG） and plasma glucose 2 h （PG2 h） were detected for confirmation of the success of establishing type 2 diabetic rat model. Systolic, diastolic radial and circumferential velocities, displacements and deformations （strains and strain rates） in 6 different segments of left ventricular wall were tested by STI in 6 weeks. Results A total of eight rats were included in type 2 diabetic group with FPG〉7.0 mmol/L and （or） PG2 h〉ll.1 mmol/L in 3 weeks. In 6 weeks, STI analysis showed significant reductions in systolic, diastolic radial and circumferential velocities and displacements in some of the segments when comparing diabetic group with control group （P〈0.05）; but no significant changes in the average systolic, diastolic radial and circumferential velocities and displacements were found （P〉0.05）. However, diastolic radial and circumferential stains in the 6 different segments, the average diastolic radial and circumferential stains in the 6 different segments, the average systolic and diastolic radial stain rates significantly decreased in diabetic group compared to control group （P〈0.05）. Conclusions Left ventricular systolic and diastolic dysfunction can be detected by STI in early stage of type 2 diabetic rat model. Deformation is more sensitive in evaluation of left ventricular function than velocity and displacement.

关 键 词：斑点追踪成像技术 速度 位移与形变 2型糖尿病 左心功能 大鼠 

分 类 号：R540.4[医药卫生—心血管疾病]