神经分泌素Secretoneurin的研究进展  

Research progress of secretoneurin

作　　者：舒琥[1] 杨丽冬[1] 李水生[2] 林婷婷[3] 

机构地区：[1]广州大学生命科学学院,广东广州510006 [2]中山大学水生经济动物研究所暨广东省水生经济动物繁殖重点实验室,广东广州510275 [3]湛江师范学院基础教育学院,广东湛江524037

出　　处：《广州大学学报（自然科学版）》2015年第5期18-23,共6页Journal of Guangzhou University:Natural Science Edition

基　　金：广东省自然科学基金资助项目(2015A030313509);中央农业科技推广专项资助项目(粤财农2012480号);广东省科技专项资金社会主义新农村建设项目(2012A020602063)

摘　　要：神经分泌素（SN）是分泌粒蛋白II（SgII）前体最保守的序列,由33～34个氨基酸组成.在硬骨鱼类的世系中,可能发生特定的基因组复制事件产生SN的两个旁系同源基因：SNa和SNb.在所有已知SN肽的中央核心都包含“YTPQ-X-LA-X7-EL”这10个相同的氨基酸.SN免疫反应（SN-ir）在哺乳动物主要的垂体细胞类型中发现.其内分泌功能最显著的例子是刺激金鱼垂体和小鼠LβT2促性腺激素细胞中促黄体生成素的释放,表明SN在生殖调控中有重要作用.研究表明,SN受体有可能是一个G蛋白偶联受体.文章对SN的起源、结构、调控垂体激素及其作用机制等方面的最新研究进展予以综述,并展望了SN今后的发展前景.Secretoneurin (SN)is derived from the most conservative sequence of the precursor secretogranin II (SgII),consists of 33 ~34 amino acids.In the teleost lineage,the specific genome duplication events that may occur to produce both paralogs of SN:SNa and SNb.In all known SN peptides,it contains 10 same amino acid with signature YTPQ-X-LA-X7-EL of the central core.Secretoneurin immunoreactivity (SN-ir)is found in the primarily mammalian pituitary cell types.The most notable example of the endocrine function of SN is the stimu-lation on luteinizing hormone release from goldfish pituitary cells and mouse LβT2 gonadotroph cells,which sug-gests that SN plays an important role in the regulation of reproduction.Studies have shown that SN receptor may be a G protein-coupled receptors.In this paper,we summarize the origin and structure of Secretoneurin,regula-ting the hormone of pituitary and mechanism of action for SN in the recent research progress.The research of SN trends for the future development prospects are proposed.

关 键 词：神经分泌素 分泌粒蛋白II 促黄体生成素 

分 类 号：Q514.3[生物学—生物化学]