山楂消脂胶囊中大黄蒽醌类成分一测多评法的建立  

Determination of Four Anthraquinones in Shanzha Xiaozhi Capsules by QAMS

作　　者：李影雄[1] 李子鸿[1] 刘东文[1] 陈淑映[1] 王汝上 

机构地区：[1]佛山市中医院,广东佛山528000 [2]广州康臣药物研究有限公司,广东广州510663

出　　处：《中国中医药信息杂志》2016年第1期89-92,共4页Chinese Journal of Information on Traditional Chinese Medicine

摘　　要：目的建立山楂消脂胶囊中大黄蒽醌类成分一测多评法的分析方法,并进行方法学考察。方法以大黄素为内参照物,建立芦荟大黄素、大黄酸和大黄酚与大黄素间的相对校正因子。分别采用外标法和一测多评法测定山楂消脂胶囊中4种蒽醌类成分的含量,以验证一测多评法的合理性、可行性和可重复性。结果一测多评法的计算结果与外标法的实测值之间无显著差异。结论一测多评法可作为一种质量评价模式用于山楂消脂胶囊中蒽醌类成分的质量评价。Objective To establish a method for the quantitative analysis of multi-component with a single-marker (QAMS) to determine the contents of four rhubarb anthraquinones inShanzha Xiaozhi capsules; To conduct methodology investigation.Methods Emodin was set as the internal reference substance, and the relative correlation factors of aloe emodin, rhein, chrysophanol to emodin were calculated and evaluated. The contents of these four anthraquinones were determined by the external standard method and QAMS, respectively. Rationality, feasibility and repeatability of the QAMS method were verified by comparing the results obtained from the two different methods. Results The QAMS method and HPLC method did not show significant difference in results.Conclusion QAMS method can be used as a quality assessment model for quantity evaluation of anthraquinones inShanzha Xiaozhi Capsules.

关 键 词：一测多评法 高效液相色谱法 山楂消脂胶囊 蒽醌 相对校正因子 

分 类 号：R284.1[医药卫生—中药学]