血压正常人群中血清游离脂肪酸与脉压水平的相关研究  

Study on the relationship between serum free fatty acids and pulse pressure among normotensives

作　　者：刘娜[1] 张曼[1] 

机构地区：[1]北京大学第九临床医学院首都医科大学附属北京世纪坛医院医学检验科,北京100038

出　　处：《中国卫生检验杂志》2015年第23期3988-3990,共3页Chinese Journal of Health Laboratory Technology

基　　金：863重大专项子课题(2011AA02A111);首都卫生发展科研专项(2011-2008-02)

摘　　要：目的探讨在血压正常人群中血清游离脂肪酸水平与脉压间的关系。方法入选1 250例非高血压人员为研究对象,测量并计算脉压（PP）和体重指数（BMI）。检测空腹游离脂肪酸等血脂参数水平。依脉压水平分为脉压升高组（PP〉50 mm Hg）和脉压未升高组（PP≤50 mm Hg）,比较组间临床特征的差异。采用多因素Logistic回归分析各临床及检验参数与脉压的关系。结果脉压升高组的平均年龄、血清总胆固醇水平、低密度脂蛋白水平均高于脉压未升高组,差异有统计学意义（P〈0.05）。脉压升高组的空腹血清游离脂肪酸水平明显升高,差异具有统计学意义（P=0.000）。多因素Logistic回归分析显示空腹血清游离脂肪酸水平是脉压升高的独立危险因素（OR=0.985,95%CI：0.962~0.997,P=0.018）。结论非高血压人群中高游离脂肪酸水平是脉压升高的独立危险因素,进行游离脂肪酸水平的检查可能有助于筛查出动脉硬化高危人群。Objective To explore the relation between serum free fatty acids（ FFA） and pulse pressure among normotensives.Methods A total of 1 250 non-hypertensive participants were recruited. The pulse pressure（ PP） and body mass index（ BMI） were measured and calculated,and the fasting serum free fatty acids levels were detected. According to pulse pressure level,there were the PP increasing group（ PP 50 mm Hg） and PP non-increasing group（ PP≤50 mm Hg）,and the differences on clinical features between the two groups were compared. Multiple Logistic regression analysis was conducted on the relationship between clinical and test parameters and pulse pressure. Results The average age,total serum cholesterol,and low density lipoprotein levels in PP increasing group were higher than that in PP non-increasing group,and the differences were statistically significant（ P〈0. 05）. While,free fatty acids level increased significantly,and the differences were statistically significant（ P = 0. 000）. Multiple Logistic regression analysis showed that fasting serum free fatty acid levels were independent risk factors for PP increasing（ OR = 0. 985,95% CI： 0. 962-0. 997,P = 0. 018）. Conclusion In people without hypertention,FFA level was associated with the increases in pulse pressure. This finding may help to screen the early detection of people with atherosclerosis.

关 键 词：游离脂肪酸 脉压 高血压 

分 类 号：R544.1[医药卫生—心血管疾病]