手足口病早期患儿IL-2、IL-4、IL-5、IL-8检测的临床价值  

Clinical significance of the detection of IL-2,IL-4,IL-5,IL-8 in children with early hand-foot-mouth disease

作　　者：韩雪[1] 程江[1] 马雅静[1] 左维泽[1,2] 张蕾[1] 蔡钢[3] 

机构地区：[1]石河子大学医学院第一附属医院检验科,新疆石河子832002 [2]石河子大学医学院第一附属医院传染性疾病科,新疆石河子832002 [3]石河子大学医学院第一附属医院中医科,新疆石河子832002

出　　处：《中国卫生检验杂志》2015年第23期4071-4073,4076,共4页Chinese Journal of Health Laboratory Technology

基　　金：新疆生产建设兵团科技局兵团科技攻关计划课题(20-13BA061)

摘　　要：目的探讨手足口病患儿发病早期心肌酶谱及IL-2、IL-4、IL-5、IL-8水平变化。方法收集248例手足口病患儿血清,根据心肌酶谱分为心肌酶异常组125例、心肌酶正常组123例,另选取104例健康体检儿童血清作为对照组,用ELISA法检测IL-2、IL-4、IL-5、IL-8水平。结果心肌酶正常组和心肌酶异常组与对照组比较IL-2、IL-4、IL-8水平差异均有统计学意义(P<0.05),但心肌酶正常组与心肌酶异常组之间差异无统计学意义(P>0.05)。心肌酶异常组IL-5水平与心肌酶正常组相比有所升高,较对照组则明显升高,差异均有统计学意义(P<0.05)。结论IL-2、IL-4、IL-5、IL-8在手足口病发病早期具有一定的临床诊断价值,发病早期心肌酶是否异常不能单独作为病情严重程度的判定标准。其中IL-5联合心肌酶在手足口病早期感染阶段可能有一定价值。Objective To study the diversify of myocardial enzymes spectrum and IL-2,IL-4,IL-5 and IL-8 in children with early hand-foot-mouth disease（ HFMD）. Methods 248 cases of serum from HFMD patient children were collected and divided into the normal myocardial enzymes group（ n = 123） and the abnormal myocardial enzymes group（ n = 125） according to myocardial enzymes spectrum,and 104 cases of serum from healthy children were taken as control group. The IL-2,IL-4,IL-5 and IL-8 levels were tested by enzyme-link immunosorbent assay（ ELISA）. Results The differences of the IL-2,IL-4,IL-8 levels among normal myocardial enzymes group,abnormal myocardial enzymes group and the control group were statistically significant（ P〈0. 05）,but there was no statistical significance on the difference between the normal myocardial enzymes group and the abnormal myocardial enzymes group（ P〈0. 05）. The IL-5 level in the abnormal myocardial enzymes group increased,compared with the that in the mormal myocardial enzymes group,and increased significantly compared with the that in the health control group,with the differences all statistically significant among the three groups（ P〈0. 05）. Conclusion IL-2,IL-4,IL-5 and IL-8 has clinical diagnostic value in the early stage of HFMD,while,the abnormality of myocardial enzymes can not be used as a criterion alone for the severity of the disease. And the combined detection of IL-5 and myocardial enzymes may have some value in the early stage of HFMD.

关 键 词：手足口病 心肌酶谱 细胞因子 早期诊断 

分 类 号：R512.5[医药卫生—内科学]